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E6010 is a novel modified t-PA, in which cysteine 84 in the epidermal growth factor domain has been replaced by serine. This is the first modified t-PA to be effective by i.v. bolus injection, and it has a prolonged half-life (Tα1/2 > 20 min) compared to native t-PA.A randomized, double-blind multicenter trial of i.v. bolus injection of E601 0, 27,500 EU/kg, compared with native t-PA (cell culture),...
E6010 is a novel modified t-PA, in which cysteine 84 in the epidermal growth factor domain has been replaced by serine. This is the first modified t-PA to be effective by i.v. bolus injection, and it has a prolonged half-life (Tα1/2 > 20 min) compared to native t-PA.A randomized, double-blind multicenter trial of i.v. bolus injection of E601 0, 27,500 EU/kg, compared with native t-PA (cell culture),...