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The effect of Shiga-like toxin II (SLT-II), which was derived from Escherichia coli O157:H7, on doxorubicin transport across the blood-brain barrier (BBB) and P-glycoprotein function, was investigated in ddY mice. Doxorubicin (30 mg kg -1 ) was administered intravenously or fluorescein isothiocyanate labeled dextran (FD-4) was infused (20 μg min -1 ) to the mice, who had...