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Estrogens are considered essential to the mechanism for closure of epiphyses in both males and females. The mechanism for this, however, is still unclear. It is likely that estrogen acts directly on growth plate chondrocytes, but the localization of the cells expressing the estrogen receptor (ER) has yet to be ascertained. Moreover, in rodents, growth plates remain open well into adult life. Whether...
Two families are described in whom both fathers were found to be hypocalcaemic when their sons presented with fits and hypocalcaemia in infancy. The diagnosis was assumed to be familial hypoparathyroidism and treatment with calcium supplements and vitamin D analogues was started. This treatment, whilst correcting hypocalcaemia, produced a rise in serum creatinine. One child repeatedly developed...
Coeliac disease is a major cause of intestinal malabsorption which has important effects on the absorption of calcium and hence is likely to impact upon the skeleton. In order to assess the effect of coeliac disease on bone we have measured the bone mass in 27 patients with histologically proven coeliac disease who had been prescribed a gluten free diet.Bone mass was measured using QCT of the spine,...
A variety of new markers of bone turnover have been described recently To investigate the ability of two of these to characterise patients with postmenopausal osteoporosis we have compared the levels of PICP and ICTP with histomorphometric findings.Fourty two women with postmenopausal osteoporosis underwent transiliac bone biopsy prior to commencement of treatment. At the same time blood was obtained...
Assessment of calcium intake is important for an understanding of the relationship between calcium nutrition and bone status. Most previous means of assessing calcium intake have been difficult and time consuming. We report the results of using an abbreviated dietary history to assess the calcium intake in a group of subjects with a variety of different disorders of mineral metabolism.23 patients...
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