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As part of an ongoing study of the response of the Streptococcus pneumoniae population to conjugate vaccination, we applied multi-locus sequence typing (MLST) to 291 isolates sampled from nasopharyngeal carriage in Massachusetts children. We found 94 distinct sequence types (STs), including 19 that had not been previously recorded, and a xpt allele containing a large insertion. Comparison with a similar...
Treatment of age-macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and capable of delivering multiple drugs. Avastin ® was the drug of interest in...
In addition to the previously documented mechanisms of salt withdrawal, dissolution and differential sedimentary loading, it is recognized that gravity-driven thin-skinned extension above inclined salt layers has played an important part in North Sea basin development. Commercial section restoration software has been used to facilitate depth conversion, restoration and decompaction of seismic sections...
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