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The Cdc7–Dbf4 complex is a conserved serine/threonine protein kinase essential for the initiation of eukaryotic DNA replication. Although an mcm5–bob1 mutation bypasses lethality conferred by mutations in CDC7 or DBF4, the Δcdc7 mcm5–bob1 mutant is sensitive to hydroxyurea (HU), which induces replication stress. To elucidate the reasons for HU sensitivity conferred by deletion of CDC7, we examined...