Search results for: Tina K. Machu

Items from 1 to 10 out of 10 results

article

Therapeutics of 5-HT3 receptor antagonists: Current uses and future directions

Tina K. Machu

Pharmacology and Therapeutics > 2011 > 130 > 3 > 338-347

The 5-Hydroxytryptamine ₃ (5-HT ₃ ) receptor is a member of the cys-loop family of ligand gated ion channels, of which the nicotinic acetylcholine receptor is the prototype. All other 5-HT receptors identified to date are metabotropic receptors. The 5-HT ₃ receptor is present in the central and peripheral nervous systems, as well as a number of non-nervous tissues. As an ion...

article

Hydrophobic Photolabeling Studies Identify the Lipid−Protein Interface of the 5-HT _3A Receptor

Mitesh Sanghvi, Ayman K. Hamouda, Margaret I. Davis, Russell A. Morton, more

Biochemistry > 2009 > 48 > 39 > 9278 - 9286

article

The Role of Loop F Residues in Determining Differential d -Tubocurarine Potencies in Mouse and Human 5-Hydroxytryptamine 3A Receptors ^†

Ran Zhang, Xiaofei Wen, Julius Militante, Brent Hester, more

Biochemistry > 2007 > 46 > 5 > 1194 - 1204

article

Temperature: An important experimental variable in studying PKC modulation of ligand-gated ion channels

Tina K. Machu, Glenn H. Dillon, RenQi Huang, David M. Lovinger, more

Brain Research > 2006 > 1086 > 1 > 1-8

Amphibian oocyte and mammalian heterologous expression systems are often used to investigate the function of recombinant ion channels using electrophysiological techniques. Although both systems have yielded important information, the results obtained in these systems are sometimes conflicting. Oocytes and mammalian cells differ in their physiological temperature requirements. While room temperature...

article

Assessing the Lipid Requirements of the Torpedo californica Nicotinic Acetylcholine Receptor ^†

Ayman K. Hamouda, Mitesh Sanghvi, Daniel Sauls, Tina K. Machu, more

Biochemistry > 2006 > 45 > 13 > 4327 - 4337

article

Co-expression of the 5-HT3B subunit with the 5-HT3A receptor reduces alcohol sensitivity

Volodya Hayrapetyan, Monica Jenschke, Glenn H. Dillon, Tina K. Machu

Molecular Brain Research > 2005 > 142 > 2 > 146-150

Allosteric modulation of mouse 5-Hydroxytryptamine _3A (5-HT _3A ) and 5-HT _3A/B receptor function by ethanol and trichloroethanol (TCEt) was assessed in HEK293 cells with whole cell patch-clamp electrophysiological recordings. Ethanol enhanced 5-HT _3A receptor function, but had no effect on mouse 5-HT _3A/B receptor mediated currents. The enhancing action of trichloroethanol...

article

ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane

Thomas L. Freeman, Geoffrey M. Thiele, Dean J. Tuma, Tina K. Machu, more

Archives of Biochemistry and Biophysics > 2002 > 400 > 2 > 215-222

System A, the Na ⁺ -dependent amino acid transport activity, is encoded by the ATA2 gene and up-regulated following partial hepatectomy (PH), and its competitive inhibition interferes with liver regeneration. Rabbit polyclonal antibody was raised against a portion of the ATA2 gene product followed by immunodetection of ATA2 in isolated liver plasma membrane and lysate. The level of ATA2 increased...

article

Characterization of distinct system a amino acid transport activities during liver regeneration by xenopus oocyte expression and chemical modification

Thomas L. Freeman, Hao Q. Ngo, Tina K. Machu, Mark E. Mailliard

Gastroenterology > 2000 > 118 > 4 Part 1 > A932

article

Colchicine competitively antagonizes glycine receptors expressed in Xenopus oocytes

Tina K. Machu

Neuropharmacology > 1998 > 37 > 3 > 391-396

Ligand-gated ion channel association with the cytoskeleton may play an important role in receptor distribution and function. However, the microtubule depolymerizing agent, colchicine, has inhibitory effects on glycine receptors that are independent of microtubule depolymerization. The actions of colchicine and other microtubule-modifying drugs were examined on glycine α1 and α2 receptors expressed...

article

Tyrosine kinase phosphorylation of GABA _A receptors

C. Fernando Valenzuela, Tina K. Machu, Ruth M. McKernan, Paul Whiting, more

Molecular Brain Research > 1995 > 31 > 1-2 > 165-172

Phosphorylation of purified bovine brain GABA _A receptors by the tyrosine kinase, pp60 ^v ^- ^s ^r ^c was examined. pp60 ^v ^- ^s ^r ^c phosphorylated two bands of 54-62 kDa and 48-51 kDa that migrated to approximately the same position as bands recognized by antisera against the β2 and γ2 GABA _A receptor subunits, respectively. Bacterially expressed...

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