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Hepatocellular carcinoma (HCC) occurs predominantly in patients with liver cirrhosis. Here we show an innovative RNA‐based targeted approach to enhance endogenous albumin production while reducing liver tumor burden. We designed short‐activating RNAs (saRNA) to enhance expression of C/EBPα (CCAAT/enhancer‐binding protein‐α), a transcriptional regulator and activator of albumin gene expression. Increased...
Intracellular adaptor signalling proteins are members of a large family of mediators crucial for signal transduction pathways. Structurally, these molecules contain one Src Homology 2 (SH2) domain and one or more Src Homology 3 (SH3) domain(s); with either a catalytic subunit, or with other non-catalytic modular subunits. Cells depend on these regulatory signalling molecules to transmit information...
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