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Metabotropic glutamate receptors (mGluRs) are a heterogenous family of G-protein coupled receptors that are linked to multiple second messenger systems. We report here the discovery of (±)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate, LY314582. This conformationally constrained amino diacid is related to the non selective mGluR agonist L-CCG1. Both LY314582 and L-CCG1 are highly potent agonists...
Metabotropic glutamate receptors (mGluRs) are a heterogeneous family of G-protein coupled receptors that are linked to multiple second messengers in the rat hippocampus. The compound 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) has been widely used to activate this class of receptors and study their functions in situ. However, 1S,3R-ACPD acts on multiple mGluR subtypes to produce...
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