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It has been shown for head and neck squamous cell carcinomas (HNSCC), that a specific gene expression profile in the primary tumor has predictive value for the presence of a lymph node metastasis. It is possible that these expression profiles are a result of acquired cancer-associated genetic aberrations during tumorigenesis. The alternative hypothesis, based on genetic studies in the mouse, is that...
Patients with advanced head and neck squamous cell carcinomas (HNSCC) are often treated with concomitant chemotherapy and radiotherapy, but only 50% is cured. A possible explanation for treatment failure is therapy resistance of the cancer stem cells (CSCs). The application of compounds specifically targeting these CSCs, in addition to routinely used therapeutics, would likely improve clinical outcome...
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