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Limited availability of allele‐level HLA genotypes prompts their imputation from allele‐group genotypes to estimate epitope mismatches. We evaluated the accuracy of epitope load and repertoire assignment when imputing allele‐level HLA genotypes. Analyses were conducted on 175 hematopoietic stem cell (HSC) donors from the Héma‐Québec registry (HQR) and 57 HSC donor‐recipient pairs from McGill University...
During the 15th International Histocompatibility and Immunogenetics Workshop (IHIWS), 14 human leukocyte antigen (HLA) laboratories participated in the Analysis of HLA Population Data (AHPD) project where 18 new population samples were analyzed statistically and compared with data available from previous workshops. To that aim, an original methodology was developed and used (i) to estimate frequencies...
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