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Previous literature suggests that Parkinson’s disease is marked by deficits in timed behaviour. However, the majority of studies of central timing mechanisms in patients with Parkinson’s disease have used timing tasks with a motor component. Since the motor abnormalities are a defining feature of the condition, the status of timing in Parkinson’s disease remains uncertain. Data are reported from patients...
The ability of patients with Huntington's disease (HD) and control subjects to produce rhythmic finger tapping movements at target frequencies (1-5 Hz) signalled by auditory cues, and to sustain the tapping tempo following sudden withdrawal of cues, was investigated. HD performance, in both the presence and absence of cues, was characterised by, (i) marked irregularity of instantaneous tapping rates...
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