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The ligand PK11195 binds specifically in macrophages. We have assessed the use of positron emission tomography (PET) of [ 11 C]R-PK11195 to monitor macrophage disposition following particulate challenge to the lung. Repeated PET scanning was performed over 4 weeks following iv [ 11 C]R-PK11195 in rabbits treated with 5-μm particles of either amorphous (aSiO 2 ) or...