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Differences in therapeutic outcomes after regional chemotherapy or chemo-immunotherapy in liver metastases from colorectal carcinoma cannot be explained only by variations in the regimens of treatment. This study was undertaken to assess the potential of several tumor-associated markers of biological behavior (biomarkers) to predict therapeutic response in order to pre-select the best candidates...
DNA flow cytometry was used to estimate spontaneous and therapy-induced changes in DNA profiles of breast carcinomas by comparing the findings from pre-treatment core needle biopsies and resection samples. Spontaneous diversification from primary diploid tumor to aneuploid node metastases was a rather rare event occuring in only 2% of 45 cases, 38% (1745) of which expressed p53 protein in immunohistology...
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