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Previous transgenic-reporter and targeted-deletion studies indicate that the subset-specific expression of CD8αβ heterodimers is controlled by multiple enhancer activities, since no silencer elements had been found within the locus. We have identified such a silencer as L2a, a previously characterized ∼220bp nuclear matrix associating region (MAR) located ∼4.5kb upstream of CD8α. L2a transgenes driven...
Intrathymic signals induce the differentiation of immature CD4 + CD8 + double positive (DP) thymocytes into mature CD4 + or CD8 + single positive (SP) T cells. The transcriptional mechanism by which CD8 lineage is determined is not fully understood. The best evidence, which favors the kinetic signaling/coreceptor reversal model, indicates that signaled DP thymocytes...
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