Search results for: K. Verbeken

Items from 1 to 20 out of 97 results

article

Oxygenated machine perfusion at room temperature as an alternative for static cold storage in porcine donor hearts

Vincent Suylen, Katrien Vandendriessche, Arne Neyrinck, Foppe Nijhuis, more

Background There is a continued interest in ex situ heart perfusion as an alternative strategy for donor heart preservation. We hypothesize that oxygenated machine perfusion of donor hearts at a temperature that avoids both normothermia and deep hypothermia offers adequate and safe preservation. Methods Cardioplegia‐arrested porcine donor hearts were randomly assigned to six hours of preservation...

article

Histopathologic and radiologic assessment of nontransplanted donor lungs

Arno Vanstapel, Adriana Dubbeldam, Birgit Weynand, Eric K. Verbeken, more

American Journal of Transplantation > 20 > 6 > 1712 - 1719

Donor organ shortage results in significant waiting list mortality. Donor lung assessment is currently based on donors’ history, gas exchange, chest X‐ray, bronchoscopy findings, and ultimately in situ inspection but remains subjective. We correlated histopathology and radiology in nontransplanted donor lungs with the clinical indications to decline the offered organ. Sixty‐two donor lungs, not used...

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Mortality after lung transplantation: a single‐centre cohort analysis

Jo Raskin, Arno Vanstapel, Eric K. Verbeken, Hanne Beeckmans, more

Transplant International > 33 > 2 > 130 - 141

Detailed data on postoperative death in lung transplant (LTx) recipients are lacking. Therefore, we investigated all deaths after LTx in a large, single‐centre, 25‐year follow‐up cohort. Prevalence, time, place and cause of death (COD) were retrospectively analysed for all patients undergoing primary LTx between July 1991 and December 2015 in our centre. Over subsequent years, postoperative survival...

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Total lymphoid irradiation in progressive bronchiolitis obliterans syndrome after lung transplantation: a single‐center experience and review of literature

Marnix Lebeer, Janne Kaes, Maarten Lambrech, Arno Vanstapel, more

Transplant International > 33 > 2 > 216 - 228

Limited results about treatment with total lymphoid irradiation (TLI) in lung transplant (LTx) recipients suffering from progressive bronchiolitis obliterans syndrome (BOS) have been reported. We performed a retrospective analysis of all LTx recipients undergoing TLI for progressive BOS in our center, focusing on long‐term outcomes regarding overall survival and lung allograft function. Treatment...

article

Granulomatous lung disease in two workers making light bulbs

Steven Ronsmans, Eric K Verbeken, Els Adams, Stephan Keirsbilck, more

American Journal of Industrial Medicine > 62 > 10 > 908 - 913

Background Associations between sarcoidosis or sarcoid‐like granulomatous lung disease and exposure to silica and other inorganic agents have been suggested in several studies. Cases We describe granulomatous lung disease in two workers of a small production unit making metal‐halide lamps. Initially, both were diagnosed with sarcoidosis. However, in both men, birefringent particles were observed...

article

Pirfenidone in restrictive allograft syndrome after lung transplantation: A case series

Robin Vos, Wim A. Wuyts, Olivier Gheysens, Karolien E. Goffin, more

American Journal of Transplantation > 18 > 12 > 3045 - 3059

Pirfenidone may attenuate the decline of pulmonary function in restrictive allograft syndrome (RAS) after lung transplantation. We retrospectively assessed all lung transplant recipients with RAS who were treated with pirfenidone for at least 3 months (n = 11) in our lung transplant center and report on their long‐term outcomes following initiation of pirfenidone. Main outcome parameters included...

article

Clinical behaviour of patients exposed to organic dust and diagnosed with idiopathic pulmonary fibrosis

Laurens J. De Sadeleer, Stijn E. Verleden, Els De Dycker, Jonas Yserbyt, more

Respirology > 23 > 12 > 1160 - 1165

Background and objective Although idiopathic pulmonary fibrosis (IPF) patients experience a worse survival compared with chronic hypersensitivity pneumonitis (CHP), organic dust exposure is a known risk factor for both IPF and CHP. Methods We divided patients diagnosed with IPF, based on their exposure to moulds/birds (absent: group A; present: group B). We retrospectively compared pulmonary function...

article

Diagnostic Ability of a Dynamic Multidisciplinary Discussion in Interstitial Lung Diseases

Laurens J. De Sadeleer, Caressa Meert, Jonas Yserbyt, Hans Slabbynck, more

Chest > 2018 > 153 > 6 > 1416-1423

The advice of a dynamic multidisciplinary discussion (MDD) is believed to be important in the diagnosis of interstitial lung diseases (ILDs). However, to what extent MDD diagnoses differ from the preliminary diagnoses before formal workup and MDD (preMDD diagnoses) is still insufficiently studied.We compared preMDD and MDD diagnoses in patients discussed at the Leuven University Hospitals MDDs between...

article

Influence of rigid body motion on the attachment of metallic droplets to solid particles in liquid slags — A phase field study

I. Bellemans, N. Moelans, K. Verbeken

Mining, Metallurgy & Exploration > 2018 > 35 > 2 > 87-97

Metallic droplets can remain attached to solid particles within liquid slags, resulting in production losses in several pyrometallurgical industries. This study shows the extension of a recently developed phase field model to include the movement of solid particles in the liquid slag in a system, considering the attachment of liquid metal droplets to solid particles in slags. The influence of this...

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The detrimental effect of hydrogen at dislocations on the hydrogen embrittlement susceptibility of Fe-C-X alloys: An experimental proof of the HELP mechanism

T. Depover, K. Verbeken

International Journal of Hydrogen Energy > 2018 > 43 > 5 > 3050-3061

The hydrogen trapping ability of 15 Fe-C-X alloys is compared in this work. Five types of carbides, i.e. Ti, Cr, Mo, W and V based carbides, and their effect on the hydrogen embrittlement susceptibility is considered while three carbon contents are prepared for each carbide former. Two conditions are compared for each alloy to evaluate the hydrogen/material interaction: an as quenched and quenched...

article

Deformation induced degradation of hot-dip aluminized steel

B. Lemmens, H. Springer, M. Peeters, I. De Graeve, more

Materials Science and Engineering: A > 2018 > 710 > C > 385-391

In this work the fracture and corrosion behaviour of hot-dip aluminized steels is investigated in controlled dipping experiments which allowed to separately study the effects of Si in the Al bath (1–10wt%) and the intermetallic phase thickness (5–30µm). The addition of Si had no direct influence on the performance of the coating system for similar thickness values of the IMP seam, which in turn showed...

article

Prevalence and clinical association of MET gene overexpression and amplification in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape project

Lukas Bubendorf, Urania Dafni, Martin Schöbel, Stephen P. Finn, more

Lung Cancer > 2017 > 111 > C > 143-149

In a well-defined NSCLC cohort of the ETOP Lungscape program, we explored the epidemiology of IHC MET overexpression and amplification, their inter-correlation, and their association to outcome.Resected NSCLC were assessed for MET gene copy number (GCN) and expression using silver in-situ hybridization (SISH) and immunohistochemistry (IHC) on TMAs in a multicenter setting. MET amplification was defined...

article

High-dose vitamin D after lung transplantation: A randomized trial

Robin Vos, David Ruttens, Stijn E. Verleden, Elly Vandermeulen, more

The Journal of Heart and Lung Transplantation > 2017 > 36 > 8 > 897-905

Vitamin D may have innate immunomodulatory functions with potentially beneficial therapeutic effects in lung transplant recipients.This was a single-center, double blind, randomized, placebo-controlled, prevention trial of once-monthly oral vitamin D (cholecalciferol; 100,000 IU, n = 44) vs placebo (n = 43) during 2 years in adult lung transplant recipients enrolled from October 2010 to August 2013...

article

Evolution of plastic deformation in heavily deformed and recrystallized tungsten of ITER specification studied by TEM

A. Dubinko, D. Terentyev, A. Bakaeva, K. Verbeken, more

International Journal of Refractory Metals and Hard Materials > 2017 > 66 > C > 105-115

Microstructure induced by plastic deformation at 600°C in as-fabricated and recrystallized tungsten grades of ITER specification is studied by means of transmission electron microscopy (TEM). Both grades are produced by AG Plansee and being used by fusion community as research material for plasma facing and high heat flux components. Reference microstructure was investigated by a combination of TEM,...

article

Post‐transplant lymphoproliferative disease in lung transplantation: A nested case‐control study

Annelies Leyssens, Daan Dierickx, Eric K. Verbeken, Thomas Tousseyn, more

Clinical Transplantation > 31 > 7 > n/a - n/a

Post‐transplant lymphoproliferative disorder (PTLD) may compromise long‐term outcome of lung transplant (LTx) recipients. A case‐control study was performed, comparing LTx recipients with PTLD (n=31) to matched recipients without PTLD (Controls, n=62). Risk factors for PTLD and post‐transplant outcomes were assessed. PTLD prevalence was 3.9%, time to PTLD 323 (166‐1132) days; and 54.8% had early‐onset...

article

Effect of silicon on the microstructure and growth kinetics of intermetallic phases formed during hot-dip aluminizing of ferritic steel

B. Lemmens, H. Springer, I. De Graeve, J. De Strycker, more

Surface and Coatings Technology > 2017 > 319 > C > 104-109

•Microstructure of hot-dip aluminized steel with rising Si content was investigated.•Si addition caused a reduction in η phase thickness and formation of ternary phases.•In the θ and η phase were respectively micro twins and a wavy structure observed.•Growth kinetics were investigated by dipping at various temperatures and times.•Activation energy for the η phase decreased with rising Si content in...

article

Influence of sample geometry and microstructure on the hydrogen induced cracking characteristics under uniaxial load

A. Laureys, T. Depover, R. Petrov, K. Verbeken

Materials Science and Engineering: A > 2017 > 690 > C > 88-95

The present work evaluates hydrogen induced cracking in a TRIP (transformation induced plasticity) assisted steel and pure iron. The goal of this work is to understand the effect of the macroscopic stress distribution in the material on the hydrogen induced cracking phenomenon. Additionally, the effect of a complex multiphase microstructure on the characteristics of hydrogen induced cracking was investigated...

article

Effect of deformation and charging conditions on crack and blister formation during electrochemical hydrogen charging

A. Laureys, E. Van den Eeckhout, R. Petrov, K. Verbeken

Acta Materialia > 2017 > 127 > C > 192-202

Hydrogen induced cracks were introduced in an ultra-low carbon (ULC) steel by subjecting it to electrochemical hydrogen charging. The damage characteristics were investigated for three material conditions, i.e. cold deformed, recovered, and recrystallized state. The aim of the work was to understand the effect of deformation induced defects on the hydrogen induced cracking of this material. Additionally,...

article

Immunological diversity in phenotypes of chronic lung allograft dysfunction: a comprehensive immunohistochemical analysis

Elly Vandermeulen, Elise Lammertyn, Stijn E. Verleden, David Ruttens, more

Transplant International > 30 > 2 > 134 - 143

Summary Chronic rejection after organ transplantation is defined as a humoral‐ and cell‐mediated immune response directed against the allograft. In lung transplantation, chronic rejection is nowadays clinically defined as a cause of chronic lung allograft dysfunction (CLAD), consisting of different clinical phenotypes including restrictive allograft syndrome (RAS) and bronchiolitis obliterans syndrome...

article

First‐in‐man observation of Talaromyces marneffei‐transmission by organ transplantation

Frederik Hermans, Sien Ombelet, Karlien Degezelle, Dries Testelmans, more

Mycoses > 60 > 3 > 213 - 217

A lung transplant recipient was diagnosed with penicilliosis due to Talaromyces marneffei, a fungus endemic in South‐East Asia, which was acquired by donor transmission. This first case of Talaromyces marneffei‐transmission by transplantation underscores that current globalisation of travelling necessitates increased vigilance for transmission of unusual pathogens in organ recipients.

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INFONA - science communication portal

Search results for: K. Verbeken

Oxygenated machine perfusion at room temperature as an alternative for static cold storage in porcine donor hearts

Histopathologic and radiologic assessment of nontransplanted donor lungs

Mortality after lung transplantation: a single‐centre cohort analysis

Total lymphoid irradiation in progressive bronchiolitis obliterans syndrome after lung transplantation: a single‐center experience and review of literature

Granulomatous lung disease in two workers making light bulbs

Pirfenidone in restrictive allograft syndrome after lung transplantation: A case series

Clinical behaviour of patients exposed to organic dust and diagnosed with idiopathic pulmonary fibrosis

Diagnostic Ability of a Dynamic Multidisciplinary Discussion in Interstitial Lung Diseases

Influence of rigid body motion on the attachment of metallic droplets to solid particles in liquid slags — A phase field study

The detrimental effect of hydrogen at dislocations on the hydrogen embrittlement susceptibility of Fe-C-X alloys: An experimental proof of the HELP mechanism

Deformation induced degradation of hot-dip aluminized steel

Prevalence and clinical association of MET gene overexpression and amplification in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape project

High-dose vitamin D after lung transplantation: A randomized trial

Evolution of plastic deformation in heavily deformed and recrystallized tungsten of ITER specification studied by TEM

Post‐transplant lymphoproliferative disease in lung transplantation: A nested case‐control study

Effect of silicon on the microstructure and growth kinetics of intermetallic phases formed during hot-dip aluminizing of ferritic steel

Influence of sample geometry and microstructure on the hydrogen induced cracking characteristics under uniaxial load

Effect of deformation and charging conditions on crack and blister formation during electrochemical hydrogen charging

Immunological diversity in phenotypes of chronic lung allograft dysfunction: a comprehensive immunohistochemical analysis

First‐in‐man observation of Talaromyces marneffei‐transmission by organ transplantation

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