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Reduced physical activity leads, in female mice, to a reduction of the average and maximal life span. The average age at death of the inactive experimental group was 497 ± 121 days (mean ± S.D.) compared to 557 ± 139 days in the active control group, and the six oldest inactive experimental mice died at age 732 ± 50 days, while the six oldest active control mice died at 890 ± 52 days. The restriction...