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This study tested the hypothesis that statins may reduce left ventricular hypertrophy (LVH) in patients with hypertension and LVH.A prospective randomised open-label study with blinded endpoints assessment was performed in 142 patients. Inclusion criteria were hypertension, left ventricular ejection fraction ≥50% and echocardiographic determined LVH, defined as a left ventricular mass index (LVMI)...
Background: Atrial arrhythmia surgery in addition to valve surgery in pts. with atrial fibrillation [AF] is advised because serial cardioversion therapy of AF after valve surgery generally fails. We investigated rhythm outcome in pts. with a history of AF who underwent mitral valve surgery in combination with a left atrial isolation [LAI] procedure.Methods: 14 pts. with significant mitral valve disease...
Background: Atrial tachycardia shortens the atrial effective refractory period (AERP), and increases induction (IND) and duration (DUR) of atrial fibrillation (AF). To determine the role of the autonomic nervous system during this so-called electrical remodeling we analyzed heart rate variability (HRV) in chronically instrumented goats.Methods: In 18 experiments in 11 goats we measured the AERP at...
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