Search results for: Diana A. Gorog

Items from 1 to 20 out of 32 results

article

Preoperative Atrial Fibrillation is associated with long‐term morTality in patients undergoing suRgical AortiC valvE Replacement

Mohamed Farag, Yusuf Kiberu, S. Ashwin Reddy, Ahmad Shoaib, more

Journal of Cardiac Surgery > 36 > 10 > 3561 - 3566

Introduction Atrial fibrillation (AF) is frequent after any cardiac surgery, but evidence suggests it may have no significant impact on survival if sinus rhythm (SR) is effectively restored early after the onset of the arrhythmia. In contrast, management of preoperative AF is often overlooked during or after cardiac surgery despite several proposed protocols. This study sought to evaluate the impact...

article

Endogenous fibrinolysis—Relevance to clinical thrombosis risk assessment

Rahim Kanji, Jacek Kubica, Eliano P. Navarese, Diana A. Gorog

European Journal of Clinical Investigation > 51 > 4 > n/a - n/a

The development of an obstructive luminal thrombus is pathological and considered a failure of endogenous fibrinolysis. The consequences may be fatal, or result in lasting downstream organ damage. Therefore, assessment of endogenous fibrinolytic status in an individual may identify those at risk of occlusive thrombus formation and provide prognostic information. Arterial thrombi are more platelet...

article

2‐Oxothiazolidine‐4‐carboxylic acid inhibits vascular calcification via induction of glutathione synthesis

Jessal J. Patel, Lucie E. Bourne, Shori Thakur, Ken Farrington, more

Journal of Cellular Physiology > 236 > 4 > 2696 - 2705

Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous antioxidants, such as glutathione (GSH), may prevent calcification. GSH synthesis, however, can be limited by cysteine levels. Therefore, we assessed the effects of the cysteine prodrug...

article

MINOCA presenting with STEMI: incidence, aetiology and outcome in a contemporaneous cohort

Ying X. Gue, Natasha Corballis, Alisdair Ryding, Juan Carlos Kaski, more

Journal of Thrombosis and Thrombolysis > 2019 > 48 > 4 > 533-538

Historical data indicate that approximately 10% of acute coronary syndrome patients have no obstructive coronary artery disease (CAD) but contemporary incidence of non-obstructed coronary arteries in ST-segment elevation myocardial infarction (STEMI) is not clear. We aimed both to identify the contemporary incidence of MI without obstructive CAD (MINOCA)—using the ESC definition—and assess clinical...

article

Impaired endogenous fibrinolysis at high shear using a point-of-care test in STEMI is associated with alterations in clot architecture

Nikolaos Spinthakis, Ying Gue, Mohamed Farag, Guogang Ren, more

Journal of Thrombosis and Thrombolysis > 2019 > 47 > 3 > 392-395

Impaired endogenous fibrinolysis is an adverse prognostic biomarker in acute coronary syndrome (ACS). Abnormally dense in vitro fibrin thrombi have been demonstrated in ACS patients and related to hypofibrinolysis using cumbersome, laboratory-based methods. We aimed to assess endogenous fibrinolysis using a point-of-care technique and relate this to clot architecture. From patients with ST-segment...

article

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications

Diana A. Gorog

Journal of Thrombosis and Thrombolysis > 2018 > 45 > 4 > 593-602

The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis. There is ample evidence from both laboratory and clinical studies to suggest that in addition to inhibiting platelet aggregation, antithrombotic medications have shear-dependent...

article

Percutaneous coronary intervention with drug-eluting stent versus coronary artery bypass grafting: A meta-analysis of patients with left main coronary artery disease

Nikolaos Spinthakis, Mohamed Farag, Diana A. Gorog, Abhiram Prasad, more

International Journal of Cardiology > 2017 > 249 > C > 101-106

The relative efficacy and safety of percutaneous coronary intervention (PCI) with drug-eluting stents (DES), in comparison to coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) remains controversial.We performed a meta-analysis of randomised studies comparing patients with LMCAD treated with PCI with DES versus those treated with CABG, with respect to clinical outcomes...

article

Arterial Thrombus Stability

Diana A. Gorog, Zahi A. Fayad, Valentin Fuster

Journal of the American College of Cardiology > 2017 > 70 > 16 > 2036-2047

The spontaneous lysis of a coronary thrombus is a natural protective mechanism against lasting occlusion and downstream infarction. Thrombus stability is thus a direct determinant of clinical outcome. Compared with the extensive study of the crucial role of platelets, coagulation, and flow in arterial thrombosis, little attention has been paid to factors affecting thrombus stability, despite evidence...

article

Catheter ablation for AF improves global thrombotic profile and enhances fibrinolysis

Maria Niespialowska-Steuden, Vias Markides, Mohamed Farag, David Jones, more

Journal of Thrombosis and Thrombolysis > 2017 > 44 > 4 > 413-426

Patients with atrial fibrillation (AF) are at increased risk of thrombotic events despite oral anticoagulation (OAC). Radiofrequency catheter ablation (RFCA) can restore and maintain sinus rhythm (SR) in patients with AF. To assess whether RFCA improves thrombotic status. 80 patients (71% male, 64 ± 12y) with recently diagnosed AF, on OAC and scheduled to undergo RFCA or DC cardioversion (DCCV) were...

article

Allopurinol as a therapeutic option in cardiovascular disease

Osita N Okafor, K Farrington, Diana A Gorog

Pharmacology & Therapeutics > 2017 > 172 > C > 139-150

Epidemiological studies indicate that hyperuricaemia is an independent risk factor for cardiovascular disease. Alongside uric acid formation, increased xanthine oxidase activity also results in the formation of oxidative free radicals and superoxide particles. Oxidative stress significantly contributes to the development of cardiovascular disease, including endothelial cell dysfunction, atherosclerosis,...

article

CHANGES IN THROMBOTIC PARAMETERS IN PATIENTS WITH REFRACTORY ANGINA AND RAISED LIPOPROTEIN(A) TREATED WITH LIPOPROTEIN APHERESIS

Tina Z. Khan, Mahmoud Barbir, Dudley J. Pennell, Diana A. Gorog

Journal of the American College of Cardiology > 2017 > 69 > 11(S) > 209

article

“Mind the gap” acute coronary syndrome in women: A contemporary review of current clinical evidence

Elizabeth Davis, Diana A. Gorog, Charanjit Rihal, Abhiram Prasad, more

International Journal of Cardiology > 2017 > 227 > C > 840-849

The incidence and prevalence of coronary artery disease in women has exceeded that in men over the past four decades, and although a significant decline in mortality has occurred in the past two decades, there is a growing body of evidence suggesting that there are gender differences between the clinical manifestations and course of coronary artery disease, as well as differences in treatment and...

article

Endogenous Fibrinolysis

Osita N. Okafor, Diana A. Gorog

Journal of the American College of Cardiology > 2015 > 65 > 16 > 1683-1699

Most acute cardiovascular events are attributable to arterial thrombosis. Plaque rupture or erosion stimulates platelet activation, aggregation, and thrombosis, whilst simultaneously activating enzymatic processes that mediate endogenous fibrinolysis to physiologically maintain vessel patency. Interplay between these pathways determines clinical outcome. If proaggregatory factors predominate, the...

article

ATRIAL FIBRILLATION ABLATION IMPROVES GLOBAL THROMBOTIC STATUS THROUGH ENDOGENOUS THROMBOLYSIS, AS EARLY AS 3 MONTHS POST ABLATION

Maria Niespialowska-Steuden, Vias Markides, Osita Okafor, Mohamed Farag, more

Journal of the American College of Cardiology > 2015 > 65 > 10(S) > A421

article

Global Thrombosis Test – a possible monitoring system for the effects and safety of dabigatran

Kazunori Otsui, Diana A. Gorog, Junichiro Yamamoto, Takayuki Yoshioka, more

Thrombosis Journal > 2015 > 13 > 1 > 1-5

Background Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage of dabigatran over WF is that monitoring is not required; however, a method to monitor the effect and the safety of dabigatran is not currently available. The Global Thrombosis Test (GTT) is a novel method to assess both clot formation...

article

Novel oral anticoagulants in acute coronary syndrome

Charis Costopoulos, Maria Niespialowska-Steuden, Neville Kukreja, Diana A. Gorog

International Journal of Cardiology > 2013 > 167 > 6 > 2449-2455

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide with a prevalence that has now reached pandemic levels as a consequence of the rapid modernization of the developing world. Its presentation as an acute coronary syndrome (ACS) is a frequent reason for hospital admission and of profound implications for personal, societal and global health. Despite improvements in...

article

Platelet Function Tests in Clinical Cardiology

Diana A. Gorog, Valentin Fuster

Journal of the American College of Cardiology > 2013 > 61 > 21 > 2115-2129

This review is a critical evaluation of publications in the past decade on the usefulness of platelet function tests (PFTs) in clinical cardiology, in aiding diagnosis, predicting risk, and monitoring therapy. The ideal PFT should: 1) detect baseline platelet hyperreactivity; 2) allow individualization of antiplatelet medication; 3) predict thrombotic risk; and 4) predict bleeding risk. The practicalities...

article

PAR-1 ANTAGONIST VORAPAXAR IMPROVES GLOBAL THROMBOTIC STATUS IN PATIENTS WITH CORONARY DISEASE

Diana A. Gorog, Christos Christopoulos, Maria N. Niespialowska-Steuden, Robert Kozarski, more

Journal of the American College of Cardiology > 2013 > 61 > 10(S) > E223

article

Use of thrombectomy devices in primary percutaneous coronary intervention: A systematic review and meta-analysis

Charis Costopoulos, Diana A. Gorog, Carlo Di Mario, Neville Kukreja

International Journal of Cardiology > 2013 > 163 > 3 > 229-241

Primary percutaneous coronary intervention (PPCI) has become the treatment of choice in patients with ST-elevation myocardial infarction (STEMI) over the recent years. A number of studies have demonstrated a morbidity and mortality benefit over thrombolysis, which has been attributed to better coronary perfusion in patients undergoing PPCI. However although PPCI usually achieves normal flow in the...

article

Novel antithrombotic agents for atrial fibrillation

Maria M. Niespialowska-Steuden, Vias Markides, Diana A. Gorog

Pharmacology and Therapeutics > 2012 > 134 > 3 > 345-354

Atrial fibrillation (AF) is the most common cardiac arrhythmia. It is estimated that 1 in 4 individuals aged 40years or above will develop at least 1 episode of AF during their lifetime. Stroke is a leading cause of serious, long-term disability and death, and a major socioeconomic burden in developed countries. The major risk factor for thromboembolic stroke is AF. Oral antithrombotic treatment for...

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Keywords

MYOCARDIAL INFARCTION (6)
THROMBOSIS (6)
ATRIAL FIBRILLATION (4)
FIBRINOLYSIS (4)
ACUTE CORONARY SYNDROME (3)
PLATELET AGGREGATION (3)
PLATELETS (3)
THROMBOLYSIS (3)
CARDIOVASCULAR (2)
HSP27 (2)
ISCHEMIA (2)
MORTALITY (2)
2‐OXOTHIAZOLIDINE‐4‐CARBOXYLIC ACID (1)
ABLATION (1)
ACCESSORY PATHWAY (1)
AGGREGATION (1)
ANGINA (1)
ANGIOPLASTY (1)
ANTICOAGULANTS (1)
ANTIMYCIN A (1)
ANTITHROMBOTIC DRUGS (1)
AORTIC VALVE REPLACEMENT (1)
ARTERIAL MEDIAL CALCIFICATION (1)
ASPIRIN (1)
ATHEROSCLEROSIS (1)
BIOMARKER (1)
CARDIOVERSION (1)
CATHETER ABLATION (1)
CLOPIDOGREL (1)
CLOT LYSIS (1)
CONGENIC STRAINS (1)
CONTRACTILE FUNCTION (1)
CORONARY ARTERY BYPASS GRAFTING (1)
CORONARY ARTERY DISEASE (1)
D-DIMER (1)
DIRECT FACTOR XA INHIBITORS (1)
DIRECT THROMBIN INHIBITORS (1)
ENDOGENOUS FIBRINOLYSIS (1)
GLUTATHIONE (1)
HALO (1)
HIBERNATION (1)
IMAGING (1)
ISCHEMIC PRECONDITIONING (1)
KNOCKOUT MICE (1)
LEFT MAIN STEM (1)
LIPID HYDROPEROXIDES (1)
LIPOPROTEIN (A) (1)
MAP KINASE (1)
MAPKAPK-2 (1)
MAPPING (1)
MINOCA (1)
NO-REFLOW (1)
NOVEL ANTICOAGULANTS (1)
NOVEL ORAL ANTICOAGULANTS (1)
P38 MAPK (1)
P38-MAP KINASE (1)
P38-MAPK (1)
PAI-1 (1)
PCI (1)
PERCUTANEOUS CORONARY INTERVENTION (1)
PLATELET ACTIVATION (1)
PLATELET FUNCTION TEST (1)
PLATELET FUNCTION TESTS (1)
PREGNANCY (1)
PRIMARY PERCUTANEOUS CORONARY INTERVENTION (1)
RACE (1)
REACTIVE OXYGEN SPECIES (1)
RIGHT FREE WALL (1)
SB203580 (1)
ST ELEVATION MYOCARDIAL INFARCTION (1)
STABILITY (1)
STEMI (1)
STROKE (1)
THROMBECTOMY (1)
THROMBIN (1)
THROMBOEMBOLISM (1)
THROMBUS (1)
THROMBUS ASPIRATION (1)
THROMBUS DISPERSION (1)
TPA (1)
TUMOR NECROSIS FACTOR (1)
VASCULAR SMOOTH MUSCLE CELLS (1)
VENOUS THROMBOSIS (1)
VENTRICULAR FUNCTION (1)
VITAMIN K ANTAGONISTS (1)
WARFARIN (1)
WOMEN (1)
ΑB-CRYSTALLIN (1)
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Data set

Elsevier (21)
Springer (8)
Wiley (3)

INFONA - science communication portal

Search results for: Diana A. Gorog

Preoperative Atrial Fibrillation is associated with long‐term morTality in patients undergoing suRgical AortiC valvE Replacement

Endogenous fibrinolysis—Relevance to clinical thrombosis risk assessment

2‐Oxothiazolidine‐4‐carboxylic acid inhibits vascular calcification via induction of glutathione synthesis

MINOCA presenting with STEMI: incidence, aetiology and outcome in a contemporaneous cohort

Impaired endogenous fibrinolysis at high shear using a point-of-care test in STEMI is associated with alterations in clot architecture

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications

Percutaneous coronary intervention with drug-eluting stent versus coronary artery bypass grafting: A meta-analysis of patients with left main coronary artery disease

Arterial Thrombus Stability

Catheter ablation for AF improves global thrombotic profile and enhances fibrinolysis

Allopurinol as a therapeutic option in cardiovascular disease

CHANGES IN THROMBOTIC PARAMETERS IN PATIENTS WITH REFRACTORY ANGINA AND RAISED LIPOPROTEIN(A) TREATED WITH LIPOPROTEIN APHERESIS

“Mind the gap” acute coronary syndrome in women: A contemporary review of current clinical evidence

Endogenous Fibrinolysis

ATRIAL FIBRILLATION ABLATION IMPROVES GLOBAL THROMBOTIC STATUS THROUGH ENDOGENOUS THROMBOLYSIS, AS EARLY AS 3 MONTHS POST ABLATION

Global Thrombosis Test – a possible monitoring system for the effects and safety of dabigatran

Novel oral anticoagulants in acute coronary syndrome

Platelet Function Tests in Clinical Cardiology

PAR-1 ANTAGONIST VORAPAXAR IMPROVES GLOBAL THROMBOTIC STATUS IN PATIENTS WITH CORONARY DISEASE

Use of thrombectomy devices in primary percutaneous coronary intervention: A systematic review and meta-analysis

Novel antithrombotic agents for atrial fibrillation

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