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Adenocarcinomas of the upper gastrointestinal tract (UGI) show remarkable male predominance. As smoking is a well-established risk factor, we investigated the role of tobacco smoking in the male predominance of UGI adenocarcinomas in the United States NIH-AARP Diet and Health Study.A questionnaire was completed by 281,422 men and 186,133 women in 1995–1996 who were followed until 31st December 2003...
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