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Sorafenib is an anti-angiogenic agent associated with increased overall survival in patients with unresectable hepatocellular carcinoma. However, adverse effects (diarrhea and hand-foot syndrome) of this oral agent limit compliance, and other routes of sorafenib delivery have not been explored. Sorafenib infusion from a transarterial approach may impart high intrahepatic drug concentrations to reduce...
In cancer chemopreventive studies, test agents are typically administered via diet, while the preclinical safety studies normally employ oral gavage dosing. Correspondence in pharmacokinetic and pharmacodynamic profiles between the two dosing approaches cannot be assumed a priori. Sulindac, a non-steroidal anti-inflammatory agent with potential chemopreventive activity, was used to assess effects...
A methanol extract of chaste-tree berry (Vitex agnus-castus L.) was tested for its ability to displace radiolabeled estradiol from the binding site of estrogen receptors alpha (ERα) and beta (ERβ). The extract at 46 ± 3 μg/ml displaced 50% of estradiol from ERα and 64 ± 4 μg/ml from ERβ. Treatment of the ER+ hormone-dependent T47D:A18 breast cancer cell line with the extract induced up-regulation...
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