Search results for: Yannick Le Marchand-Brustel

Items from 1 to 15 out of 15 results

article

Reply to: “C-reactive protein levels in non-alcoholic fatty liver disease”

Tine Jess, Esther Zimmermann, Rodolphe Anty, Joan Tordjman, more

Journal of Hepatology > 2012 > 56 > 2 > 508-510

article

C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients

Esther Zimmermann, Rodolphe Anty, Joan Tordjman, An Verrijken, more

Journal of Hepatology > 2011 > 55 > 3 > 660-665

Non-alcoholic fatty liver disease (NAFLD) is a major hepatic consequence of obesity. It has been suggested that the high sensitivity C-reactive protein (hs-CRP) is an obesity-independent surrogate marker of severity of NAFLD, especially development of non-alcoholic steato-hepatitis (NASH), but this remains controversial. We aimed to investigate whether associations between various features of NAFLD...

article

Dimethyl sulfoxide enhances GLUT4 translocation through a reduction in GLUT4 endocytosis in insulin-stimulated 3T3-L1 adipocytes

Marion Berenguer, Jinzhong Zhang, M. Christine Bruce, Laurène Martinez, more

Biochimie > 2011 > 93 > 4 > 697-709

Insulin increases muscle and fat cell glucose uptake by inducing the translocation of glucose transporter GLUT4 from intracellular compartments to the plasma membrane. Here, we have demonstrated that in 3T3-L1 adipocytes, DMSO at concentrations higher than 7.5% augmented cell surface GLUT4 levels in the absence and presence of insulin, but that at lower concentrations, DMSO only enhanced GLUT4 levels...

article

Liquid Chromatography−Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease

Jonathan Barr, Mercedes Vázquez-Chantada, Cristina Alonso, Miriam Pérez-Cormenzana, more

Journal of Proteome Research > 2010 > 9 > 9 > 4501 - 4512

article

Rosiglitazone increases cell surface GLUT4 levels in 3T3-L1 adipocytes through an enhancement of endosomal recycling

Laurène Martinez, Marion Berenguer, M. Christine Bruce, Yannick Le Marchand-Brustel, more

Biochemical Pharmacology > 2010 > 79 > 9 > 1300-1309

Insulin induces a translocation of the glucose transporter GLUT4 from intracellular storage compartments towards the cell surface in adipocytes and skeletal muscle cells, allowing the cells to take up glucose. In type 2 diabetes-associated insulin resistance, the efficiency of this process is reduced. The thiazolidinediones, widely prescribed as anti-diabetic therapy, are generally regarded as insulin-sensitizers...

article

GLUT4 molecules are recruited at random for insertion within the plasma membrane upon insulin stimulation

Marion Berenguer, Yannick Le Marchand-Brustel, Roland Govers

FEBS Letters > 2010 > 584 > 3 > 537-542

Glucose transporter 4 (GLUT4) is efficiently retained intracellularly. Here, we investigated the insulin-induced reduction of retention. While increasing insulin concentrations led to gradual increases in both the amount of recycling GLUT4 molecules and cell surface GLUT4 levels, the kinetics of the increase in time was independent of insulin concentration. To determine whether there are GLUT4 subpools...

article

Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH

Soumeya Bekri, Philippe Gual, Rodolphe Anty, Nathalie Luciani, more

Gastroenterology > 2006 > 131 > 3 > 788-796

Backgrounds & Aims: Hepcidin is an acute-phase response peptide. We have investigated the possible involvement of hepcidin in massive obesity, a state of chronic low-grade inflammation. Three groups of severely obese patients with or without diabetes or nonalcoholic steatohepatitis were investigated. Methods: Hepcidin expression was studied in liver and adipose tissue of these patients. Hepcidin...

article

The interaction between the adaptor protein APS and Enigma is involved in actin organisation

Romain Barrès, Teresa Gonzalez, Yannick Le Marchand-Brustel, Jean-François Tanti

Experimental Cell Research > 2005 > 308 > 2 > 334-344

APS (adaptor protein with PH and SH2 domains) is an adaptor protein phosphorylated by several tyrosine kinase receptors including the insulin receptor. To identify novel binding partners of APS, we performed yeast two-hybrid screening. We identified Enigma, a PDZ and LIM domain-containing protein that was previously shown to be associated with the actin cytoskeleton. In HEK 293 cells, Enigma interacted...

article

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

Philippe Gual, Yannick Le Marchand-Brustel, Jean-François Tanti

Biochimie > 2005 > 87 > 1 > 99-109

This review will provide insight on the current understanding of the regulation of insulin signaling in both physiological and pathological conditions through modulations that occur with regards to the functions of the insulin receptor substrate 1 (IRS1). While the phosphorylation of IRS1 on tyrosine residue is required for insulin-stimulated responses, the phosphorylation of IRS1 on serine residues...

article

Potential role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in insulin-stimulated glucose transporter 4 translocation in adipocytes

Sophie Grillo, Thierry Grémeaux, Yannick Le Marchand-Brustel, Jean-François Tanti

FEBS Letters > 1999 > 461 > 3 > 277-279

Insulin stimulation of Glut 4 translocation requires the activation of phosphatidylinositol 3-kinase (PI 3-kinase) but the downstream pathway remains ill-defined. We demonstrated that the overexpression of PDK1 (3-phosphoinositide-dependent protein kinase 1), a downstream effector of PI 3-kinase, stimulated Glut 4 translocation in adipocytes. This effect does not require the PH domain of PDK1, but...

article

Characterization of 6-deoxy-6-iodo-d-glucose: A Potential New Tool to Assess Glucose Transport

Christelle Henry, Jean-François Tanti, Thierry Grémeaux, Christophe Morin, more

Nuclear Medicine and Biology > 1997 > 24 > 1 > 99-104

6-deoxy-6-iodo-d-glucose (6-DIG) was rapidly taken up by adipocytes. Insulin increased 6-DIG transport in adipocytes isolated from both rats and mice. This stimulation was more important in rat than in mouse adipocytes, in agreement with their respective amount of Glut 4 transporters. In two insulin-resistant states, the biological behavior of 6-DIG and 3-O-methyl-d-glucose was similar. These results...

article

Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states

Jean-Marc Ricort, Jean-François Tanti, Mireille Cormont, Emmanuel Van Obberghen, more

FEBS Letters > 1994 > 347 > 1 > 42-44

Insulin-induced Glut 4 and Rab4 movements were studied in two insulin-resistant states. In adipocytes from streptozotocin diabetic rats, the amount of Glut 4 was decreased by 60%. The remaining Glut 4 molecules were translocated in response to insulin, and in parallel, Rab4 left the intracellular compartment. In contrast, in 3T3-L1 adipocytes rendered insulin-resistant by a prolonged insulin treatment,...

article

Insulin affects only initiation and not elongation in protein synthesis in soleus muscles of lean and obese mice

Solange Monier, Yannick Le Marchand-Brustel

FEBS Letters > 1982 > 147 > 2 > 211-214

The effect of insulin on polypeptide chain initiation and elongation has been studied in soleus muscles isolated from lean and goldthioglucose-obese mice. Insulin increased the amount of radioactivity present in nascent chains by ~30% in muscles from both lean and obese mice, indicating that it stimulates peptide chain initiation. In contrast, elongation rates, estimated by measurement of half transit...

article

Alteration of glycogen synthase activation by insulin in soleus muscles of obese mice

Yannick Le Marchand-Brustel, Pierre Freychet

FEBS Letters > 1980 > 120 > 2 > 205-208

article

Insulin activates glycogen synthase in phosphorylase kinase deficient mice

Yannick Le Marchand-Brustel, Patricia T.W. Cohen, Philip Cohen

FEBS Letters > 1979 > 105 > 2 > 235-238

Filter options

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Yannick Le Marchand-Brustel

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options