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We have purified from Vipera lebetina venom a family of inhibitors of platelet aggregation, named Lebetins. They are composed of two peptide groups of short (Lebetin 1: L1α: GDNKPPKKGPPNG; L1β: DNKPPKKGPPNG) and long (Lebetin 2: L2α: GDNKPPKKGPPNGCFGHKIDRIGSHSGLGCNKVDDNKG; L2β: DNKPPKKGPPNGCFGHKIDRIGSHSGLGCNKVDDNKG) size. The sequence presenting anti-platelet activity is mainly present within the...
We have analysed cytokine levels in the sera of 46 patients admitted for scorpionic envenomation and 10 healthy controls. Twenty patients had fever and/or severe clinical manifestations and 26 had neither fever nor severe clinical manifestations (benign envenomation). The IL1β, TNFα, IFNγ and IL6 levels were analysed by ELISA in serum samples obtained as soon as possible after the prick. A second...
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