Search results for: Martin P Grobusch

Items from 1 to 20 out of 110 results

article

Immunogenicity of a 5‐dose pneumococcal vaccination schedule following allogeneic hematopoietic stem cell transplantation

Hannah M. Garcia Garrido, Sabine Haggenburg, Marieke C. E. Schoordijk, Ellen Meijer, more

American Journal of Hematology > 97 > 5 > 592 - 602

The optimal schedule of pneumococcal vaccination after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) remains controversial. The objective of this study was to investigate the immunogenicity of a 5‐dose pneumococcal vaccination schedule in adult allo‐HSCT recipients with and without immunosuppressive therapy. In this prospective cohort study, allo‐HSCT recipients received four doses...

article

Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19

Lihui Guo, Bernadette Schurink, Eva Roos, Esther J Nossent, more

The Journal of Pathology > 256 > 3 > 256 - 261

COVID‐19 is a pandemic with high morbidity and mortality. In an autopsy cohort of COVID‐19 patients, we found extensive accumulation of the tryptophan degradation products 3‐hydroxy‐anthranilic acid and quinolinic acid in the lungs, heart, and brain. This was not related to the expression of the tryptophan‐catabolizing indoleamine 2,3‐dioxygenase (IDO)‐1, but rather to that of its isoform IDO‐2, which...

article

Evaluating the cascade of care for hypertension in Sierra Leone

Tessa J. M. Geraedts, Daniel Boateng, Karel C. Lindenbergh, Diede Delft, more

Tropical Medicine & International Health > 26 > 11 > 1470 - 1480

Objective To assess the care for hypertension in Sierra Leone, by the use of a cascade‐of‐care approach, to identify where the need for healthcare system interventions is greatest. Methods Using data from a nationwide household survey on surgical conditions undertaken in 1956 participants ≥18 years from October 2019 to March 2020, a cascade of care for hypertension consisting of four categories...

article

The child ecosystem and childhood pulmonary tuberculosis: A South African perspective

Teresa DeAtley, Lesley Workman, Grant Theron, Sabine Bélard, more

Pediatric Pulmonology > 56 > 7 > 2212 - 2222

Introduction This study investigates drivers of childhood pulmonary tuberculosis (PTB) using a childhood ecosystem approach in South Africa. An ecosystem approach toward identifying risk factors for PTB may identify targeted interventions. Methods Data were collected as part of a prospective cohort study of children presenting at a primary care facility or tertiary hospital with possible TB. Characterization...

article

First evidence for continuous circulation of hepatitis A virus subgenotype IIA in Central Africa

Haruka Abe, Yuri Ushijima, Rodrigue Bikangui, Georgelin N. Ondo, more

Journal of Viral Hepatitis > 27 > 11 > 1234 - 1242

Although a high seroprevalence of antibodies against hepatitis A virus (HAV) has been estimated in Central Africa, the current status of both HAV infections and seroprevalence of anti‐HAV antibodies remains unclear due to a paucity of surveillance data available. We conducted a serological survey during 2015‐2017 in Gabon, Central Africa, and confirmed a high seroprevalence of anti‐HAV antibodies...

article

Tropical pyomyositis: an update

Adebayo Shittu, Stefanie Deinhardt‐Emmer, Jonathan Vas Nunes, Silke Niemann, more

Tropical Medicine & International Health > 25 > 6 > 660 - 665

Tropical pyomyositis (TP) is a life‐threatening bacterial infection of the skeletal muscle that occurs particularly among children, young adults and those with immunocompromised conditions. The appropriate diagnosis and treatment are often delayed due to its non‐specific signs, leading to fatal consequences. Staphylococcus aureus, especially methicillin‐susceptible S. aureus, is responsible for most...

article

Ongoing evolution of hepatitis B virus during viremia in patients with febrile in Central Africa

Haruka Abe, Yuri Ushijima, Rodrigue Bikangui, Marguerite M. Loembe, more

Journal of Medical Virology > 92 > 2 > 251 - 256

Hepatitis B virus (HBV) infection remains to be a major public health issue worldwide, although there is currently a safe vaccine and effective antiviral treatments. In surveillance of infectious diseases in Gabon, HBV viremia was detected in patients with febrile. Whole‐genome sequencing was conducted to characterize the HBV strains currently circulating in Gabon and to investigate HBV genome diversity...

article

Chest ultrasound compared to chest X‐ray for pediatric pulmonary tuberculosis

Charlotte C. Heuvelings, Sabine Bélard, Savvas Andronikou, Henrique Lederman, more

Pediatric Pulmonology > 54 > 12 > 1914 - 1920

Introduction Chest ultrasound is increasingly used to radiologically diagnose childhood pneumonia, but there are limited data on its use for pulmonary tuberculosis (PTB). Aim Compare chest ultrasound with a chest X‐ray (CXR) findings. Methods Children (up to 13 years) with suspected PTB were enrolled. Bedside chest ultrasound findings were compared to CXR. The analysis was stratified by PTB category:...

article

Early loss of immunity against measles following allogeneic hematopoietic stem cell transplantation

Hannah M. Garcia Garrido, Mariëlle Aalst, Janke Schinkel, Gerrit Koen, more

American Journal of Hematology > 94 > 10 > E270 - E272

article

Chest ultrasound findings in children with suspected pulmonary tuberculosis

Charlotte C. Heuvelings, Sabine Bélard, Savvas Andronikou, Norme Jamieson‐Luff, more

Pediatric Pulmonology > 54 > 4 > 463 - 470

Introduction Chest ultrasound is increasingly used for the diagnosis of pediatric lung disease but there are limited data for its use in pediatric pulmonary tuberculosis (PTB). Aim To describe chest ultrasound findings in children with suspected PTB. Methods Consecutive children, presenting with suspected PTB to a tertiary children's hospital in Cape Town between July 2014 and March 2016, were...

article

Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis

Patricia Schlagenhauf, Martin P. Grobusch, Davidson H. Hamer, Hilmir Asgeirsson, more

Malaria Journal > 2018 > 17 > 1 > 1-9

Background Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature review to elucidate key attributes of malaria in this group with a focus on possible areas of acquisition of malaria and treatment challenges. Results A total of 146 cases were identified...

article

Ebola 2018 – Implications for travel health advice and relevance for travel medicine

Martin P. Grobusch, Frieder Schaumburg, Thomas Weitzel, Camilla Rothe, more

Travel Medicine and Infectious Disease > 2018 > 24 > C > 1-3

article

Travel-related leptospirosis in the Netherlands 2009–2016: An epidemiological report and case series

Sophia G. de Vries, Maud M.I. Bekedam, Benjamin J. Visser, Cornelis Stijnis, more

Travel Medicine and Infectious Disease > 2018 > 24 > C > 44-50

Leptospirosis is a potentially fatal zoonotic disease that is prevalent in travellers. Here, we describe epidemiological and diagnostic characteristics of all returning travellers diagnosed with leptospirosis in the Netherlands between 2009 and 2016. Furthermore, we present a detailed clinical case series of all travellers with leptospirosis who presented at the Academic Medical Center (AMC) in the...

article

Incidence of invasive pneumococcal disease in immunocompromised patients: A systematic review and meta-analysis

Mariëlle van Aalst, Felix Lötsch, René Spijker, Jan T.M. van der Meer, more

Travel Medicine and Infectious Disease > 2018 > 24 > C > 89-100

Invasive pneumococcal disease (IPD) is associated with high morbidity and mortality, with immunocompromised patients (ICPs) at particular risk. Therefore, guidelines recommend pneumococcal vaccination for these patients. However, guidelines are scarcely underpinned with references to incidence studies of IPD in this population. This, potentially results in unawareness of the importance of vaccination...

article

Management of superficial and deep-seated Staphylococcus aureus skin and soft tissue infections in sub-Saharan Africa: a post hoc analysis of the StaphNet cohort

Abraham Alabi, Theckla Kazimoto, Marthe Lebughe, Delfino Vubil, more

Infection > 2018 > 46 > 3 > 395-404

Purpose The incidence of Staphylococcus aureus skin and soft tissue infection (SSTI) is high in sub-Saharan Africa. This is fueled by a high prevalence of Panton-Valentine leukocidin (PVL), which can be associated with necrotizing disease. The aim was to describe the clinical presentation and the treatment of SSTI in the African setting and to identify challenges in the management. Methods Patients...

article

Fine-scale spatial and temporal variation of clinical malaria incidence and associated factors in children in rural Malawi: a longitudinal study

Alinune N. Kabaghe, Michael G. Chipeta, Steve Gowelo, Monicah Mburu, more

Parasites & Vectors > 2018 > 11 > 1 > 1-11

Background Spatio-temporal variations in malaria burden are currently complex and costly to measure, but are important for decision-making. We measured the spatio-temporal variation of clinical malaria incidence at a fine scale in a cohort of children under five in an endemic area in rural Chikhwawa, Malawi, determined associated factors, and monitored adult mosquito abundance. Methods We followed-up...

article

The role of ‘filth flies’ in the spread of antimicrobial resistance

Francis C. Onwugamba, J. Ross Fitzgerald, Kateryn Rochon, Luca Guardabassi, more

Travel Medicine and Infectious Disease > 2018 > 22 > C > 8-17

‘Filth flies’ feed and develop in excrement and decaying matter and can transmit enteric pathogens to humans and animals, leading to colonization and infection. Considering these characteristics, ‘filth flies’ are potential vectors for the spread of antimicrobial resistance (AMR). This review defines the role of flies in the spread of AMR and identifies knowledge gaps.The literature search (original...

article

Plasmodium falciparum diagnostic tools in HIV-positive under-5-year-olds in two ART clinics in Ghana: are there missed infections?

Ewurama D. A. Owusu, Samson K. Djonor, Charles A. Brown, Martin P. Grobusch, more

Malaria Journal > 2018 > 17 > 1 > 1-7

Background Plasmodium falciparum, the most dominant species in sub-Saharan Africa, causes the most severe clinical malaria manifestations. In resource-limited Ghana, where malaria and HIV geographically overlap, histidine-rich protein 2 (HRP2)-based rapid diagnostic test (RDT) is a faster, easier and cheaper alternative to clinical gold standard light microscopy. However, mutations in parasite hrp2...

article

First molecular characterization of Echinococcus granulosus (sensu stricto) genotype 1 among cattle in Sudan

Mohamed E. Ahmed, Bashir Salim, Martin P. Grobusch, Imadeldin E. Aradaib

BMC Veterinary Research > 2018 > 14 > 1 > 1-5

Background Echinococcus granulosus sensu lato (s.l.) is the causative agent of cystic echinococcosis (CE), which is a cosmopolitan zoonotic parasitic disease infecting humans and a wide range of mammalian species including cattle. Currently, little information is available on the genetic diversity of Echinococcus species among livestock in Sudan. In the present study, fifty (n = 50) hydatid cysts...

article

Hepatitis B and C in Tonkolili Province, Sierra Leone

Noemi García-Tardón, Tom M Gresnigt, Abu B Fofanah, Martin P Grobusch

The Lancet > 2017 > 390 > 10101 > 1485

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Search results for: Martin P Grobusch

Immunogenicity of a 5‐dose pneumococcal vaccination schedule following allogeneic hematopoietic stem cell transplantation

Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19

Evaluating the cascade of care for hypertension in Sierra Leone

The child ecosystem and childhood pulmonary tuberculosis: A South African perspective

First evidence for continuous circulation of hepatitis A virus subgenotype IIA in Central Africa

Tropical pyomyositis: an update

Ongoing evolution of hepatitis B virus during viremia in patients with febrile in Central Africa

Chest ultrasound compared to chest X‐ray for pediatric pulmonary tuberculosis

Early loss of immunity against measles following allogeneic hematopoietic stem cell transplantation

Chest ultrasound findings in children with suspected pulmonary tuberculosis

Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis

Ebola 2018 – Implications for travel health advice and relevance for travel medicine

Travel-related leptospirosis in the Netherlands 2009–2016: An epidemiological report and case series

Incidence of invasive pneumococcal disease in immunocompromised patients: A systematic review and meta-analysis

Management of superficial and deep-seated Staphylococcus aureus skin and soft tissue infections in sub-Saharan Africa: a post hoc analysis of the StaphNet cohort

Fine-scale spatial and temporal variation of clinical malaria incidence and associated factors in children in rural Malawi: a longitudinal study

The role of ‘filth flies’ in the spread of antimicrobial resistance

Plasmodium falciparum diagnostic tools in HIV-positive under-5-year-olds in two ART clinics in Ghana: are there missed infections?

First molecular characterization of Echinococcus granulosus (sensu stricto) genotype 1 among cattle in Sudan

Hepatitis B and C in Tonkolili Province, Sierra Leone

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