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Purpose. To investigate concentration dependent permeabilities andmetabolism kinetics of thymotrinan (TP3) versus thymocartin (TP4)in nasal epithelium in vitro. Methods. Excised bovine nasal mucosa was used as an in vitro model.Permeabilities were studied in a diffusion chamber, metabolism kineticsin a reflection kinetics set-up. Studies were performed at various TP3and TP4 concentrations. The...
Lang, S., B. Rothen-Rutishauser, J.-C. Perriard, M. C. Schmidt and H. P. Merkle. Permeation and pathways of human calcitonin (hCT) across excised bovine nasal mucosa. Peptides 19(3) 599-607, 1998.-In vitro permeation of human calcitonin (hCT), salmon calcitonin (sCT), and the somatostatin analog octreotide (SMS) through excised bovine nasal mucosa was studied applying donor/receiver experiments and...
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