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The processing and presentation of self-proteins is essential to develop an effective immune system, with almost all T cells only ever encountering self-peptide/MHC ligands. How positive selection in the thymus occurs with a weak interaction between the TCR and self-pMHC remains unresolved. The recent identification of a naturally occurring positive selecting self-peptide, gp250, for the MCC/I-E ...
The nature of peptide binding to MHC molecules is intrinsically degenerate, in that, one given MHC molecule can accommodate numerous peptides which are structurally diverse, and one given peptide can bind to different alleles. The structure of the MHC class II molecules allows peptides to extend out of the binding groove at both ends and these residues can potentially influence the stability and persistence...
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