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Chez la souris, un régime enrichi en isomères conjugués de l’acide linoléique (CLA) provoque une lipodystrophie majeure. Une étude récente (Poirier et al., Diabetes, 2006, 55 : 1634) révèle l’accumulation rapide de macrophages dans le tissu adipeux blanc de souris traitées par l’isomère actif, t10, c12-CLA, après 7 jours de gavage. Nous avons utilisé ce modèle pour caractériser la cinétique d’infiltration...
Aims/hypothesis Adipose tissue inflammation has recently been implicated in the pathogenesis of insulin resistance and is probably linked to high local levels of cytokines. IL1B, a proinflammatory cytokine, may participate in this alteration. Materials and methods We evaluated the chronic effect (1–10 days) of IL1B (0.1–20 ng/ml) on insulin signalling in differentiating 3T3-F442A and differentiated...
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