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Background & Aims: Genetic predisposition is implicated strongly in Crohn’s disease. Disease-associated mutations in NOD2/CARD15, the best-studied susceptibility gene in this disorder, explain only a small fraction of the heritability. The SAMP1/YitFc (SAMP1/Fc) mouse strain expresses many features of Crohn’s disease in humans. We bred SAMP1/Fc to disease-resistant AKR mice to identify additional...