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Background: We tested the hypothesis that vasodilatory effect of type III phosphodiesterase inhibition with amrinone (Amr) might be impaired in subjects with endothelial dysfunction.Methods: Forearm blood flow (FBF) measurements during intraarterial infusion of acetycholine (Ach), Amr and nitroglycerin (TNG) were performed using plethysmography in 10 patients with heart failure and age mached 10 control...
The mechanism of ethanol action at serotonergic neuronal systems in the brain was investigated by examining the effects of alcohols on the activity of tryptophan hydroxylase (TPH) in vitro using natural type of biopterin as cofactor. Alcohols inhibited the activity of TPH prepared from rat brain in a noncompetitive manner with respect to both the biopterin cofactor and the l-tryptophan substrate...
To investigate pathophysiological roles of endothelin-1 (ET-1) in collagen remodeling in pulmonary hypertension, we measured: (a) mRNA expression, concentration, localization of ET-1; (b) changes in types and content of collagen in the lung; (c) and confirmed direct effects of ET-1 on type V collagen metabolism in vascular smooth muscle cells. Monocrotaline-treated rats showed pulmonary hypertension...
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