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We compared the predictions of the single path convection-diffusion model (SPM) and the well-mixed single acinus model (SAM) with the normalized slopes (NS) of experimentally measured volumetric capnograms in which Vt was varied in three healthy spontaneously breathing adults. For values of Vt greater than 15 ml/kg, the tidal volume penetrates deep into the acinar airways, mixing by molecular diffusion...
The single path model (SPM) of airway gas transport with a distributed blood source term was used to simulate multiple breath inert lung gas washout of N 2 , He, and SF 6 after total body equilibration with these gases. Normalized phase III inert gas washout slopes were computed for each breath and compared with published experimental data obtained under similar conditions on human...
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