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To develop an optimized BZK gel with good pharmaceutical effect and less toxicity to vaginal mucosa. Four methods as below were used to research the spermicidal activity of BZK gel: 1) in vitro spermicidal test; 2) in vivo spermicidal test in rabbits; 3) anti-fertility test in rabbits; 4) contraceptive test in rabbits. Mucosal irritation test was used in rats to evaluate the safety of optimized...