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New dimers of known 5HT1 ligands (5HT, 1-NP or 8-OH-DPAT) have been prepared and evaluated at human cloned 5HT1b, 5HT1d and 5HT1a receptors. Binding experiments show that all these dimers have better affinities at 5HT1b1d receptors than their corresponding monomeric ligands. Studies of inhibition of the forskolin-stimulated c-AMP formation mediated by the human 5HT1b receptor show that hetero-bivalent...