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Mucopolysaccharidosis type VII (MPS VII) is a heritable lysosomal storage disease caused by a deficiency in β-glucuronidase (GUSB) activity, leading to progressive accumulation of undegraded glycosaminoglycans in many tissues. Clinical features include growth and mental retardation, hearing and visual defects, shortened lifespan, and skeletal deformities. A murine model of MPS VII has been described...
Introduction: The β2 leukocyte integrins and the endothelial ligand ICAM-1 are essential for monocyte migration through inflamed endothelium. Here we demonstrate that the integrin αvβ3 is also a key player in this process.Materials and Methods: We used FACS analysis to screen murine monocytic cell lines for expression levels of the integrin chains αv and β3. A β3 positive and a β3 deficient monocytic...
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