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N 1 -(Arylalkyl)homospermidines (1c–1f) and terminally piperazine-substituted homospermidine conjugates (2a–2e) were synthesized and evaluated for cytotoxicity in mouse leukemia L1210, α-difluoromethylornithine (DFMO)-treated L1210, melanoma B16, spermidine (SPD)-treated B16, and HeLa cell lines. Results demonstrated that homospermidine was a more effective vector than piperazine-substituted...
Ubiquitination plays a critical role in signal transduction, DNA repair, and regulation of cell activities. Alterations in the ubiquitination process are found in the majority of tumors. Therefore, the ubiquitination system is a new promising target for cancer treatment. A number of small molecules that inhibit El have been found. To understand how the inhibitors work and therefore design more potent...
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