Nicolas Manel

article

Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Eloi R. Verrier, Seung‐Ae Yim, Laura Heydmann, Houssein El Saghire, more

Hepatology > 68 > 5 > 1695 - 1709

Chronic hepatitis B virus (HBV) infection is a major cause of chronic liver disease and cancer worldwide. The mechanisms of viral genome sensing and the evasion of innate immune responses by HBV infection are still poorly understood. Recently, the cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) was identified as a DNA sensor. In this study, we investigated the functional role...

article

Mechanisms behind TB, HBV, and HIV chronic infections

David Durantel, Inca Kusters, Jacques Louis, Nicolas Manel, more

Infection, Genetics and Evolution > 2017 > 55 > C > 142-150

Immune evasion is critical for pathogens to maintain their presence within hosts, giving rise to chronic infections. Here, we examine the immune evasion strategies employed by three pathogens with high medical burden, namely, tuberculosis, HIV and HBV. Establishment of chronic infection by these pathogens is a multi-step process that involves an interplay between restriction factor, innate immunity...

article

Proceedings of the Frontiers of Retrovirology Conference 2016

Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, more

Retrovirology > 2016 > 13 > 1 > 1-40

Table of contents Oral presentations Session 1: Entry & uncoating O1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replication Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann...

article

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

Xavier Lahaye, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, more

Cell Reports > 2016 > 15 > 4 > 879-892

During the early phase of replication, HIV reverse transcribes its RNA and crosses the nuclear envelope while escaping host antiviral defenses. The host factor Cyclophilin A (CypA) is essential for these steps and binds the HIV capsid; however, the mechanism underlying this effect remains elusive. Here, we identify related capsid mutants in HIV-1, HIV-2, and SIVmac that are restricted by CypA. This...

article

Viral and cellular mechanisms of the innate immune sensing of HIV

Xavier Lahaye, Nicolas Manel

Current Opinion in Virology > 2015 > 11 > Complete > 55-62

HIV-1 replicates in immune cells that normally respond to incoming viruses and induce antiviral immune responses. Under this constant surveillance, how HIV-1 interacts with the host to escape immune control and causes immunopathology is still being untangled. Recently, a series of HIV-1 interactions with innate sensors of viruses expressed by immune target cells have been identified. Here, we review...

article

Innate immune sensing of HIV infection

Aymeric Silvin, Nicolas Manel

Current Opinion in Immunology > 2015 > 32 > C > 54-60

The ability to sense infections is primordial to preserve organisms. Immune cells express pathogen sensors that induct innate and adaptive immune responses. Understanding how HIV-1 infection defeats these responses in most individuals remains an outstanding challenge. Since HIV-1 targets immune cells, innate immune sensors are remarkably positioned at the nexus of viral replication and immunity. Here,...

article

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

Xavier Lahaye, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, more

Immunity > 2013 > 39 > 6 > 1132-1142

HIV-2 is less pathogenic for humans than HIV-1 and might provide partial cross-protection from HIV-1-induced pathology. Although both viruses replicate in the T cells of infected patients, only HIV-2 replicates efficiently in dendritic cells (DCs) and activates innate immune pathways. How HIV is sensed in DC is unknown. Capsid-mutated HIV-2 revealed that sensing by the host requires viral cDNA synthesis,...

article

Hiding in Plain Sight: How HIV Evades Innate Immune Responses

Nicolas Manel, Dan R. Littman

Cell > 2011 > 147 > 2 > 271-274

Two groups have identified SAMHD1, a protein encoded by an Aicardi-Goutières Syndrome susceptibility gene, as the factor that restricts infection of macrophages and dendritic cells with HIV-1. Here we discuss implications of this discovery for induction of antiviral protective immunity.

article

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivaylo I. Ivanov, Koji Atarashi, Nicolas Manel, Eoin L. Brodie, more

Cell > 2009 > 139 > 3 > 485-498

The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We show here that colonization of the small intestine of mice with a single commensal microbe, segmented filamentous bacterium (SFB), is sufficient to induce...

article

Response: Species Diversity in GLUT Expression and Function

Amélie Montel-Hagen, Sandrina Kinet, Nicolas Manel, Cedric Mongellaz, more

Cell > 2009 > 137 > 2 > 201-202

article

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivaylo I. Ivanov, Rosa de Llanos Frutos, Nicolas Manel, Keiji Yoshinaga, more

Cell Host & Microbe > 2008 > 4 > 4 > 337-349

The requirements for in vivo steady state differentiation of IL-17-producing T-helper (Th17) cells, which are potent inflammation effectors, remain obscure. We report that Th17 cell differentiation in the lamina propria (LP) of the small intestine requires specific commensal microbiota and is inhibited by treating mice with selective antibiotics. Mice from different sources had marked differences...

article

Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

Amélie Montel-Hagen, Sandrina Kinet, Nicolas Manel, Cédric Mongellaz, more

Cell > 2008 > 132 > 6 > 1039-1048

Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter. However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we report that glucose transport actually decreases during human erythropoiesis despite a >3-log increase in Glut1 transcripts. In contrast, Glut1-mediated transport of L-dehydroascorbic acid (DHA), an oxidized form...

article

The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest

Wei Chun Goh, Nicolas Manel, Michael Emerman

Virology > 2004 > 318 > 1 > 337-349

The human immunodeficiency virus (HIV) encodes a gene product, Vpr, which causes infected cells to arrest or delay in the G2 phase of the cell cycle. The arrest in G2 is characterized by low levels of Cyclin B1-p34Cdc2 activity and corresponding inhibitory phosphorylation of p34Cdc2. We find that Vpr directly inhibits the in vitro activity of a phosphatase, Cdc25C, which normally activates Cyclin...

article

Emergence of vertebrate retroviruses and envelope capture

Felix J. Kim, Jean-Luc Battini, Nicolas Manel, Marc Sitbon

Virology > 2004 > 318 > 1 > 183-191

Retroviruses are members of the superfamily of retroelements, mobile genetic elements that transpose via an RNA intermediate. However, retroviruses are distinct from other retroelements in that their “transposition” is not confined to single cells but extends to neighboring cells and organisms. As such, the “transposition” of these elements is defined as infection. It appears that a key step in the...

article

The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV

Nicolas Manel, Felix J. Kim, Sandrina Kinet, Naomi Taylor, more

Cell > 2003 > 115 > 4 > 449-459

The human T cell leukemia virus (HTLV) is associated with leukemia and neurological syndromes. The physiopathological effects of HTLV envelopes are unclear and the identity of the receptor, present on all vertebrate cell lines, has been elusive. We show that the receptor binding domains of both HTLV-1 and -2 envelope glycoproteins inhibit glucose transport by interacting with GLUT-1, the ubiquitous...

INFONA - science communication portal

Search results for: Nicolas Manel

Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Mechanisms behind TB, HBV, and HIV chronic infections

Proceedings of the Frontiers of Retrovirology Conference 2016

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

Viral and cellular mechanisms of the innate immune sensing of HIV

Innate immune sensing of HIV infection

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

Hiding in Plain Sight: How HIV Evades Innate Immune Responses

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Response: Species Diversity in GLUT Expression and Function

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest

Emergence of vertebrate retroviruses and envelope capture

The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Nicolas Manel

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options