Search results for: Anne Louise Oaklander

Items from 1 to 20 out of 49 results

article

Initial validation of the Mass. General Neuropathy Exam Tool (MAGNET) for evaluation of distal small‐fiber neuropathy

Gary R. Zirpoli, Khosro Farhad, Madeleine C. Klein, Sean Downs, more

Introduction/Aims Diagnosis of small‐fiber neuropathy (SFN) is hampered by its subjective symptoms and signs. Confirmatory testing is insufficiently available and expensive, so predictive examinations have value. However, few support the 2020 SFN consensus‐case‐definition requirements or were validated for non‐diabetes neuropathies. Thus we developed the Massachusetts General Hospital Neuropathy...

article

Characterization of mononeuropathy of the lateral cutaneous nerve of the calf

Anne Louise Oaklander, Trudy Van Houten, A. Sassan Sabouri

Muscle & Nerve > 64 > 4 > 494 - 499

Introduction/Aims Isolated injuries to the lateral cutaneous nerve of the calf (LCNC) branch of the common peroneal nerve can cause obscure chronic posterolateral knee and upper calf pain and sensory symptoms. Routine examination and electrodiagnostic testing do not detect them because the LCNC has no motor distribution and it is not interrogated by the typical peroneal nerve conduction study. There...

article

Fibromyalgia and small‐fiber polyneuropathy: What's in a name?

Khosro Farhad, Anne Louise Oaklander

Muscle & Nerve > 58 > 5 > 611 - 613

article

Clinical presentation, management, and pathophysiology of neuropathic itch

Martin Steinhoff, Martin Schmelz, Imre Lőrinc Szabó, Anne Louise Oaklander

The Lancet Neurology > 2018 > 17 > 8 > 709-720

Unlike conventional itch, neuropathic itch develops in normal skin from excess peripheral firing or dampened central inhibition of itch pathway neurons. Neuropathic itch is a symptom of the same central and peripheral nervous system disorders that cause neuropathic pain, such as sensory polyneuropathy, radiculopathy, herpes zoster, stroke, or multiple sclerosis, and lesion location affects symptoms...

article

Evidence of small-fiber neuropathy (SFN) in two patients with unexplained genital sensory loss and sensory urinary cystopathy

Mahmoud A. AbdelRazek, Bart Chwalisz, Anne Louise Oaklander, Nagagopal Venna

Journal of the Neurological Sciences > 2017 > 380 > C > 82-84

•SFN can occur in a non length-dependent pattern, evidenced here by the reduced ENFD in the thigh compared to the distal leg.•SFN can have both a somatic and visceral distribution, e.g. sensory cystopathy.•SFN should be added to the list of conditions that are important to rule out in cases of unexplained regional sensory changes.•First report linking unexplained somatic and visceral uro-genital sensory...

article

Initial Development and Validation of a Patient-Reported Symptom Survey for Small-Fiber Polyneuropathy

Roi Treister, Mette Lodahl, Magdalena Lang, Shelley S. Tworoger, more

The Journal of Pain > 2017 > 18 > 5 > 556-563

Small-fiber polyneuropathy (SFPN) affects unmyelinated and thinly myelinated peripheral axons. Several questionnaires have been developed to assess polyneuropathy from diabetes or chemotherapy, but none for SFPN from other or unknown causes. A comprehensive survey could help clinicians diagnose and assess treatment responses, define prevalence natural history and cures, and identify research subjects...

article

Corrigendum to “Corneal innervation as a window to peripheral neuropathies” [Exp. Eye Res. 113 (2013) 148–150]

Giulio Ferrari, Nambi Nallasamy, Heather Downs, Reza Dana, more

Experimental Eye Research > 2016 > 145 > C > 473

article

Response to the Letter to the Editor: Experimental Comparison of Parametric Versus Nonparametric Analyses of Data From the Cold Pressor Test

Roi Treister, Christopher S. Nielsen, Audun Stubhaug, John T. Farrar, more

The Journal of Pain > 2016 > 17 > 1 > 128-129

article

Immunotherapy Prospects for Painful Small-fiber Sensory Neuropathies and Ganglionopathies

Anne Louise Oaklander

Neurotherapeutics > 2016 > 13 > 1 > 108-117

The best-known peripheral neuropathies are those affecting the large, myelinated motor and sensory fibers. These have well-established immunological causes and therapies. Far less is known about the somatic and autonomic “small fibers”; the unmyelinated C-fibers, thinly myelinated A-deltas, and postganglionic sympathetics. The small fibers sense pain and itch, innervate internal organs and tissues,...

article

Experimental Comparison of Parametric Versus Nonparametric Analyses of Data From the Cold Pressor Test

Roi Treister, Christopher S. Nielsen, Audun Stubhaug, John T. Farrar, more

Journal of Pain > 2015 > 16 > 6 > 537-548

Parametric statistical methods are common in human pain research. They require normally distributed data, but this assumption is rarely tested. The current study analyzes the appropriateness of parametric testing for outcomes from the cold pressor test (CPT), a common human experimental pain test. We systematically reviewed published CPT studies to quantify how often researchers test for normality...

article

Natural history and biomarkers in hereditary sensory neuropathy type 1

Vera Fridman, Anne louise Oaklander, William S. David, Elise A. Johnson, more

Muscle & Nerve > 51 > 4 > 489 - 495

Introduction: Hereditary sensory and autonomic neuropathy type 1 (HSAN1) is most commonly caused by missense mutations in SPTLC1. In this study we mapped symptom progression and compared the utility of outcomes. Methods: We administered retrospective surveys of symptoms and analyzed results of nerve conduction, autonomic function testing (AFT), and PGP9.5‐immunolabeled skin biopsies. Results: The...

article

A 40‐year‐old woman with difficulty going down stairs in high‐heeled shoes

Patricia Scripko, Anne Louise Oaklander, Arnulf H. Koeppen, Matthew P. Frosch, more

Annals of Neurology > 77 > 1 > 1 - 7

article

Lenalidomide for Complex Regional Pain Syndrome Type 1: Lack of Efficacy in a Phase II Randomized Study

Donald C. Manning, Guillermo Alexander, Joseph C. Arezzo, Alyse Cooper, more

Journal of Pain > 2014 > 15 > 12 > 1366-1376

Complex regional pain syndrome (CRPS) is a potentially debilitating chronic pain syndrome with a poorly understood but likely neuroimmune/multifactorial pathophysiology associated with axonal injury. Based on the potential contribution of proinflammatory cytokines to CRPS pathogenesis and prior research with thalidomide, we investigated lenalidomide, a thalidomide derivative, for CRPS treatment. We...

article

Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia

Anne Louise Oaklander, Zeva Daniela Herzog, Heather M. Downs, Max M. Klein

Pain > 2013 > 154 > 11 > 2310-2316

Fibromyalgia is a common, disabling syndrome that includes chronic widespread pain plus diverse additional symptoms. No specific objective abnormalities have been identified, which precludes definitive testing, disease-modifying treatments, and identification of causes. In contrast, small-fiber polyneuropathy (SFPN), despite causing similar symptoms, is definitionally a disease caused by the dysfunction...

article

Reply to the Letter to the Editor

Anne Louise Oaklander, Zeva Daniela Herzog, Heather M. Downs, Max M. Klein

Pain > 2013 > 154 > 11 > 2569-2571

article

Corneal innervation as a window to peripheral neuropathies

Giulio Ferrari, Nambi Nallasamy, Heather Downs, Reza Dana, more

Experimental Eye Research > 2013 > 113 > C > 148-150

The cornea receives the densest sensory innervation of the body, which is exclusively from small-fiber nociceptive (pain-sensing) neurons. These are similar to those in the skin of the legs, the standard location for neurodiagnostic skin biopsies used to diagnose small-fiber peripheral polyneuropathies. Many cancer chemotherapy agents cause dose-related, therapy-limiting, sensory-predominant polyneuropathy...

article

Development of CRPS after shingles: It’s all about location

Anne Louise Oaklander

Pain > 2012 > 153 > 12 > 2309-2310

article

Cervical spinal cord injection of epidural corticosteroids: Comprehensive longitudinal study including multiparametric magnetic resonance imaging

Julien Cohen-Adad, Bradley Buchbinder, Anne Louise Oaklander

Pain > 2012 > 153 > 11 > 2292-2299

Despite widespread use, the efficacy of epidural corticosteroid injections (ESI) for osteoarthritis-associated neck or radicular pain remains uncertain, so even rare serious complications enter into discussions about use. However, various factors impede investigation and publication of serious adverse events. To that end, we developed new magnetic resonance imaging (MRI) techniques for spinal cord...

article

Response to “A new definition of neuropathic pain”

Anne Louise Oaklander, Peter R. Wilson, Peter A. Moskovitz, Donald C. Manning, more

Pain > 2012 > 153 > 4 > 934-935

article

Suprascapular neuropathy in a shoulder referral practice

Robert E. Boykin, Darren J. Friedman, Zachary R. Zimmer, Anne Louise Oaklander, more

Journal of Shoulder and Elbow Surgery > 2011 > 20 > 6 > 983-988

Suprascapular neuropathy (SSN) is considered a rare condition, and few studies have analyzed how commonly it is encountered in practice. Electrophysiologic studies are the gold standard for diagnosis; however, there is no consensus on diagnostic criteria. We hypothesized that SSN would be frequently diagnosed by electrophysiologic testing in a subset of patients with specific clinical and radiographic...

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INFONA - science communication portal

Search results for: Anne Louise Oaklander

Initial validation of the Mass. General Neuropathy Exam Tool (MAGNET) for evaluation of distal small‐fiber neuropathy

Characterization of mononeuropathy of the lateral cutaneous nerve of the calf

Fibromyalgia and small‐fiber polyneuropathy: What's in a name?

Clinical presentation, management, and pathophysiology of neuropathic itch

Evidence of small-fiber neuropathy (SFN) in two patients with unexplained genital sensory loss and sensory urinary cystopathy

Initial Development and Validation of a Patient-Reported Symptom Survey for Small-Fiber Polyneuropathy

Corrigendum to “Corneal innervation as a window to peripheral neuropathies” [Exp. Eye Res. 113 (2013) 148–150]

Response to the Letter to the Editor: Experimental Comparison of Parametric Versus Nonparametric Analyses of Data From the Cold Pressor Test

Immunotherapy Prospects for Painful Small-fiber Sensory Neuropathies and Ganglionopathies

Experimental Comparison of Parametric Versus Nonparametric Analyses of Data From the Cold Pressor Test

Natural history and biomarkers in hereditary sensory neuropathy type 1

A 40‐year‐old woman with difficulty going down stairs in high‐heeled shoes

Lenalidomide for Complex Regional Pain Syndrome Type 1: Lack of Efficacy in a Phase II Randomized Study

Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia

Reply to the Letter to the Editor

Corneal innervation as a window to peripheral neuropathies

Development of CRPS after shingles: It’s all about location

Cervical spinal cord injection of epidural corticosteroids: Comprehensive longitudinal study including multiparametric magnetic resonance imaging

Response to “A new definition of neuropathic pain”

Suprascapular neuropathy in a shoulder referral practice

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