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TSLP, IL-25 and IL-33 are primarily epithelial derived cytokines which act on common immune cell populations and individually promote pro-inflammatory responses generally with a TH2 bias. Type 2 innate lymphocytes (ILC2s) are a newly identified population of lineage negative innate immune cells which are present in a number of inflammatory disease settings capable of producing high levels of type...
The role of DNA methylation and of the maintenance DNA methyltransferase Dnmt1 in the epigenetic regulation of developmental stage- and cell lineage-specific gene expression in vivo is uncertain. This is addressed here through the generation of mice in which Dnmt1 was inactivated by Cre/loxP-mediated deletion at sequential stages of T cell development. Deletion of Dnmt1 in early double-negative thymocytes...
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