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Introduction/aims
Edaravone in amyotrophic lateral sclerosis (ALS) was analyzed in two phase 3 studies (MCI186‐16 and MCI186‐19). Those trials enrolled patients with Japanese ALS severity grades 1 and 2 (less severe ALS), but many patients progressed to grades 3 and 4 during the double‐blind treatment period. The placebo patients who initiated edaravone treatment in the open‐label periods provided...
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