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Functionalized computed tomography (CT) in combination with labelled cells is virtually non‐existent due to the limited sensitivity of X‐ray‐absorption‐based imaging, but would be highly desirable to realise cell tracking studies in entire organisms. In this study we applied in‐line free propagation X‐ray phase‐contrast CT (XPCT) in an allergic asthma mouse model to assess structural changes as well...
ObjectiveTo show that a new recombinant protein (MT07) obtained by fusing a synovial‐homing peptide to a neutralizing antibody to C5 can be selectively delivered to inflamed synovium and can effectively control joint inflammation in experimental models of arthritis.
MethodsBinding of MT07 to human, rat, and mouse synovial tissue was evaluated in vitro by immunofluorescence, and selective localization...
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