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Intra-articular injection of Freund’s complete adjuvant (FCA) into the rat knee joint produces a swelling of the joint and long lasting hypersensitivity. In this study we have used this model and in vivo electrophysiology to investigate the timecourse of spinal changes underlying chronic secondary hypersensitivity, by stimulating the ankle joint (an area outside the site of primary hypersensitivity),...
The voltage dependence and channel-blocking kinetics of uncompetitive NMDA receptor antagonists have been well-described using in vitro techniques, but there is little evidence concerning the functional significance of these properties in vivo. We have now compared the effects of NMDA antagonists that display varied profiles of voltage-dependent block in vitro, on responses of spinal neurones in anaesthetised...
Currents elicited by electrical stimulation of the ventral root were recorded from motoneurones of the immature rat spinal cord in vitro using the patch pipette technique. Control medium contained Ca 2+ (1.5 mM) and Mg 2+ (0.75 mM). In nine preparations the mean amplitude of antidromic current responses was 5.12 ± 0.41 nA. Raising Mg 2+ (EC 50 ...
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