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B cells diversify and affinity mature their antigen receptor repertoire in germinal centers (GCs). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions in the light zone sustain the subsequent proliferative program of selected B cells that occurs in the anatomically distant dark zone. Here, we show that the transcription...
Failure of T cells to protect against cancer is thought to result from lack of antigen recognition, chronic activation, and/or suppression by other cells. Using a mouse sarcoma model, we show that glucose consumption by tumors metabolically restricts T cells, leading to their dampened mTOR activity, glycolytic capacity, and IFN-γ production, thereby allowing tumor progression. We show that enhancing...
The cycloalkene–ozone reaction impacts atmospheric chemistry as a non-photochemical source of hydroxyl radical (OH) and as a source of secondary organic aerosol. Unlike in the ozonolysis of acyclic alkenes, the Criegee Intermediates (CI’s) formed in cycloalkene ozonolysis retain all of the energy released in the reaction, enabling these CI’s to access reaction pathways with high activation barriers...
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