Search results for: Mahesh M. Mansukhani

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Refractory celiac disease type II: An atypical case highlighting limitations of the current classification system

Craig R. Soderquist, Susan Hsiao, Mahesh M. Mansukhani, Bachir Alobeid, more

Hematological Oncology > 38 > 3 > 399 - 405

Refractory celiac disease (RCD) is a rare condition associated with high morbidity that develops in individuals with celiac disease. It is known to be biologically heterogeneous, and currently two types are recognized based on immunophenotypic and molecular features, type I (RCD I) and type II (RCD II). Differentiating between RCD I and RCD II is critical, as patients with RCD II have substantially...

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Cytogenetic analysis of 130 renal oncocytomas identify three distinct and mutually exclusive diagnostic classes of chromosome aberrations

Christopher B. Anderson, Michael Lipsky, Subhadra V. Nandula, Christopher E. Freeman, more

Genes, Chromosomes and Cancer > 59 > 1 > 6 - 12

The cytogenetic alterations in renal oncocytoma (RO) are poorly understood. We analyzed 130 consecutive RO for karyotypic alterations. Clonal chromosome abnormalities were identified in 63 (49%) cases, which could be categorized into three classes of mutually exclusive cytogenetic categories. Class 1 (N = 20) RO had diploid karyotypes with characteristic 11q13 rearrangement in balanced translocations...

article

Cytogenetic analysis of 130 renal oncocytomas identify three distinct and mutually exclusive diagnostic classes of chromosome aberrations

Christopher B. Anderson, Michael Lipsky, Subhadra V. Nandula, Christopher E. Freeman, more

Genes, Chromosomes and Cancer > n/a - n/a

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Clinical Genomic Profiling of a Diverse Array of Oncology Specimens at a Large Academic Cancer Center

Anthony N. Sireci, Vimla S. Aggarwal, Andrew T. Turk, Tatyana Gindin, more

The Journal of Molecular Diagnostics > 2017 > 19 > 2 > 277-287

Large cancer panels are being increasingly used in the practice of precision medicine to generate genomic profiles of tumors with the goal of identifying targetable variants and guiding eligibility for clinical trials. To facilitate identification of mutations in a broad range of solid and hematological malignancies, a 467-gene oncology panel (Columbia Combined Cancer Panel) was developed in collaboration...

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Mutant allele specific imbalance in oncogenes with copy number alterations: Occurrence, mechanisms, and potential clinical implications

Chih-Chieh Yu, Wanglong Qiu, Caroline S. Juang, Mahesh M. Mansukhani, more

Cancer Letters > 2017 > 384 > C > 86-93

Mutant allele specific imbalance (MASI) was initially coined to describe copy number alterations associated with the mutant allele of an oncogene. The copy number gain (CNG) specific to the mutant allele can be readily observed in electropherograms. With the development of genome-wide analyses at base-pair resolution with copy number counts, we can now further differentiate MASI into those with CNG,...

article

Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations

Jennifer A. Oberg, Julia L. Glade Bender, Maria Luisa Sulis, Danielle Pendrick, more

Genome Medicine > 2016 > 8 > 1 > 1-19

Background Molecular characterization has the potential to advance the management of pediatric cancer and high-risk hematologic disease. The clinical integration of genome sequencing into standard clinical practice has been limited and the potential utility of genome sequencing to identify clinically impactful information beyond targetable alterations has been underestimated. Methods The Precision...

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A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma

Filemon S. Dela Cruz, Daniel Diolaiti, Andrew T. Turk, Allison R. Rainey, more

Genome Medicine > 2016 > 8 > 1 > 1-17

Background Precision medicine approaches are ideally suited for rare tumors where comprehensive characterization may have diagnostic, prognostic, and therapeutic value. We describe the clinical case and molecular characterization of an adolescent with metastatic poorly differentiated carcinoma (PDC). Given the rarity and poor prognosis associated with PDC in children, we utilized genomic analysis...

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Lymphoid follicle colonization by Bcl-2bright+CD10+ B-cells (“follicular lymphoma in situ”) at nodal and extranodal sites can be a manifestation of follicular homing of lymphoma

John C. Lee, Daniela Hoehn, Jordan Schecter, Vundavalli V. Murty, more

Human Pathology > 2013 > 44 > 7 > 1328-1340

Follicular lymphoma (FL) in situ (FLIS) was first described and proposed as a distinct entity associated with an indolent clinical course in 2002. To gain further insight into the biology of this enigmatic lymphoproliferation, we analyzed morphologic, phenotypic, cytogenetic and molecular features of tissue specimens manifesting a pattern of follicular colonization by Bcl-2 ^bright+ CD10 ...

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Real‐time PCR‐based analysis of BRAF V600E mutation in low and intermediate grade lymphomas confirms frequent occurrence in hairy cell leukaemia

Mark Ewalt, Subhadra Nandula, Adrienne Phillips, Bachir Alobeid, more

Hematological Oncology > 30 > 4 > 190 - 193

Hairy cell leukaemia (HCL) is a rare type of B‐cell non‐Hodgkin lymphoma (B‐NHL), which is not known to be associated with any characteristic recurrent karyotypic abnormality. A recent study that used massively parallel whole exome sequencing identified an activating V600E mutation in BRAF, which appeared specific for HCL. Here, we confirm the specificity of BRAF V600E for HCL among low and intermediate...

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Cytogenetic abnormalities in reactive lymphoid hyperplasia: byproducts of the germinal centre reaction or indicators of lymphoma?

Deborah W. Sevilla, Vundavalli V. Murty, Xin‐Lai Sun, Subhadra V. Nandula, more

Hematological Oncology > 29 > 2 > 81 - 90

Non‐random karyotypic abnormalities associated with non‐Hodgkin lymphomas (NHLs) have been described in cases of reactive lymphoid hyperplasia (RLH). However, the frequency and types of cytogenetic aberrations detected and their clinical relevance are unknown. To address these questions, we undertook a retrospective analysis of a large series of RLH diagnosed at our institute over 8 years. Cytogenetic...

article

Tissue Response to Surgical Energy Devices

Courtney K. Phillips, Gregory W. Hruby, Evren Durak, Daniel S. Lehman, more

Urology > 2008 > 71 > 4 > 744-748

There is little data available on the effects of energy-based surgical devices (ESD) on tissues other than arteries and veins. As such, we quantified the lateral thermal damage associated with contemporary ESD: the Harmonic ACE, a prototype bipolar device known as the Gyrus Trisector, the Harmonic LCS-C5, and the LigaSure V.We divided 24 domestic pigs into 4 groups, 1 group for each ESD tested. Segments...

article

Evaluation of Surgical Energy Devices for Vessel Sealing and Peripheral Energy Spread in a Porcine Model

Gregory W. Hruby, Franzo C. Marruffo, Evren Durak, Sean M. Collins, more

The Journal of Urology > 2007 > 178 > 6 > 2689-2693

Vessel sealing capabilities and the peripheral energy spread associated with currently available energy based surgical instruments were evaluated.Four groups of energy based surgical instruments were established for evaluation, including the ACE ^™ , LCS-C5 (Ethicon, Cincinnati, Ohio), LigaSure ^™ V and the prototype Trissector ^™ . In vivo vessel diameter under physiological...

article

Changes in Prognostic Significance and Predictive Accuracy of Gleason Grading System Throughout PSA Era: Impact of Grade Migration in Prostate Cancer

Robert E. Mitchell, Jay B. Shah, Manisha Desai, Mahesh M. Mansukhani, more

Urology > 2007 > 70 > 4 > 706-710

To describe the changes in the Gleason grading system over time and evaluate how a shift in Gleason grading has affected the overall predictive accuracy of the system in predicting biochemical disease-free survival after radical prostatectomy.The Columbia University Urologic Oncology Database was reviewed, and 1515 patients who met the inclusion criteria were identified who had undergone radical prostatectomy...

article

Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitis

Jennifer A. Eleazar, Lorenzo Memeo, Jeffrey S. Jhang, Mahesh M. Mansukhani, more

Journal of Hepatology > 2004 > 41 > 6 > 983-991

Progenitor cell activation with subsequent maturation to hepatocytes and cells of the biliary lineage has been demonstrated in a variety of chronic liver diseases but the kinetics and magnitude of the progenitor cell response has not been adequately studied in detail in chronic hepatitis. We undertook this study to evaluate factors responsible for the progenitor cell/ductular response and further...

article

IS HISPANIC RACE AN IMPORTANT PREDICTOR OF TREATMENT FAILURE FOLLOWING RADICAL PROSTATECTOMY FOR PROSTATE CANCER?

JOHN S. LAM, JOSHUA D. SCLAR, MANISHA DESAI, MAHESH M. MANSUKHANI, more

The Journal of Urology > 2004 > 172 > 5 Part 1 > 1856-1859

Hispanic-Americans are the fastest growing minority group in the United States. Many studies have compared prostate cancer treatment outcomes between black and white men, but few such studies have been done with Hispanic men. We compared clinical and pathological features as well as the treatment failure rate of radical prostatectomy in contemporaneously treated groups of Hispanic and white men with...

article

Renal oncocytomas with 11q13 rearrangements: cytogenetic, molecular, and immunohistochemical analysis of cyclin D1

Jeffrey S. Jhang, Gopeshwar Narayan, V.V.V.S. Murty, Mahesh M. Mansukhani

Cancer Genetics and Cytogenetics > 2004 > 149 > 2 > 114-119

Two groups of renal oncocytomas have been cytogenetically defined by the loss of one or both of chromosomes Y and 1 or by structural rearrangement involving 11q12~q13. We report five renal oncocytomas with structural chromosomal rearrangements involving 11q13 with previously unreported partner chromosomes (namely, 1, 6, and 7). For two of the five cases, a t(6;11)(p21;q13) translocation was revealed;...

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Is Hispanic Race an Independent Risk Factor for Pathological Stage in Patients Undergoing Radical Prostatectomy?

JOHN S. LAM, MANISHA DESAI, MAHESH M. MANSUKHANI, MITCHELL C. BENSON, more

The Journal of Urology > 2003 > 170 > 6 Part 1 > 2288-2291

Hispanic-Americans are the most rapidly growing population in the United States. Although many studies have assessed differences in pathological stage at radical prostatectomy between white and black American men, to our knowledge none has assessed it in Hispanic men. We compared pathological stage at radical prostatectomy in contemporaneous groups of Hispanic and white American men. A total of...

article

Alpha B-crystallin (aB-C) expression in neoplastic and non neoplastichepato-biliary disease: an immunohistochemical study

Govind Bhagat, Mahesh M. Mansukhani, James E. Goldman, Jay H. Lefkowitch

Journal of Hepatology > 2002 > 36 > Supplement 1 > 268

article

Idiopathic Hypocomplementemic Interstitial Nephritis With Extensive Tubulointerstitial Deposits

Neeraja Kambham, Glen S. Markowitz, Nozomu Tanji, Mahesh M. Mansukhani, more

American Journal of Kidney Diseases > 2001 > 37 > 2 > 388-399

Most forms of interstitial nephritis are cell mediated and lack tubulointerstitial immune deposits. These forms include allergic, infectious, and idiopathic interstitial nephritis. Immune complex deposits in the tubular basement membranes and interstitium most commonly are encountered in conjunction with glomerular diseases. Predominantly tubulointerstitial immune deposits without significant glomerular...

article

Refractory celiac disease (RCD): Histology, T-cell clonality and clinical course

Govind Bhagat, Heidrun Rotterdam, Mahesh M. Mansukhani, Peter H. Green

Gastroenterology > 2000 > 118 > 4 Part 1 > A364

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