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Desflurane (DES)-induced preconditioning is mediated by large-conductance calcium-activated potassium channels (BKCa). Whether BKCa are involved in anaesthetic-induced post-conditioning is unknown. We tested the hypothesis that DES-induced post-conditioning is mediated by BKCa upstream of the mitochondrial permeability transition pore (mPTP). Pentobarbital-anaesthetized male C57Black/6 mice were...