James C. Rose

article

Evidence for an angiotensin‐(1‐7) neuropeptidase expressed in the brain medulla and CSF of sheep

Allyson C. Marshall, Nancy T. Pirro, James C. Rose, Debra I. Diz, more

Journal of Neurochemistry > 130 > 2 > 313 - 323

Angiotensin‐(1‐7) [Ang‐(1‐7)] is an alternative product of the brain renin‐angiotensin system that exhibits central actions to lower blood pressure and improve baroreflex sensitivity. We previously identified a peptidase that metabolizes Ang‐(1‐7) to the inactive metabolite product Ang‐(1‐4) in CSF of adult sheep. This study purified the peptidase 1445‐fold from sheep brain medulla and characterized...

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Enhanced activity of an angiotensin-(1–7) neuropeptidase in glucocorticoid-induced fetal programming

Allyson C. Marshall, Hossam A. Shaltout, Nancy T. Pirro, James C. Rose, more

Peptides > 2014 > 52 > Complete > 74-81

We previously identified angiotensin converting enzyme (ACE) and an endopeptidase activity that degraded angiotensin-(1–7) [Ang-(1–7)] to Ang-(1–5) and Ang-(1–4), respectively, in the cerebrospinal fluid (CSF) of 6-month old male sheep. The present study undertook a more comprehensive analysis of the CSF peptidase that converts Ang-(1–7) to Ang-(1–4) in control and in utero betamethasone-exposed sheep...

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Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep

Allyson C. Marshall, Hossam A. Shaltout, Manisha Nautiyal, James C. Rose, more

Peptides > 2013 > 44 > Complete > 25-31

Glucocorticoids including betamethasone (BM) are routinely administered to women entering into early preterm labor to facilitate fetal lung development and decrease infant mortality; however, fetal steroid exposure may lead to deleterious long term consequences. In a sheep model of fetal programming, BM-exposed (BMX) offspring exhibit elevated mean arterial pressure (MAP) and decreased baroreflex...

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521: Renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 gender differences in fetal programmed hypertension

Ryan Stone, Yixin Su, James C. Rose

American Journal of Obstetrics and Gynecology > 2011 > 204 > 1 Supplement > S207-S208

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Seasonal protein changes support rapid energy production in hibernator brainstem

L. Elaine Epperson, James C. Rose, Rae L. Russell, Mrinalini P. Nikrad, more

Journal of Comparative Physiology B > 2010 > 180 > 4 > 599-617

During the torpor phase of mammalian hibernation when core body temperature is near 4°C, the autonomic system continues to maintain respiration, blood pressure and heartbeat despite drastic reductions in brain activity. In addition, the hibernator’s neuronal tissues enter into a protected state in which the potential for ischemia–reperfusion injury is markedly minimized. Evolutionary adaptations for...

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Combined Thyroidectomy and Renal Denervation Suppress Renin Expression and Secretion in Fetal Sheep

Kai Chen, Luke C. Carey, Nancy K. Valego, Jingfang Liu, more

Journal of the Society for Gynecologic Investigation > 2006 > 13 > 8 > 604-609

Activity of the fetal renin-angiotensin system (RAS) is developmentally regulated, increasing in late gestation toward term. Thyroid hormone and the renal nerves are both important modulators of renal RAS maturation; however, ablation of either influence alone does not totally block the aforementioned developmental late gestation increase in RAS in fetal sheep. In the current study, we used the technique...

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Acute and Long-Term Effects of Clinical Doses of Antenatal Glucocorticoids in the Developing Fetal Sheep Kidney

G. Angela Massmann, Jie Zhang, James C. Rose, Jorge P. Figueroa

Journal of the Society for Gynecologic Investigation > 2006 > 13 > 3 > 174-180

The controversy regarding potential long-term side effects of antenatal steroid administration for accelerating fetal lung maturation is still unresolved despite more than 30 years of experience. Studies in animals have demonstrated that administration of glucocorticoids during pregnancy alters renal expression of several key regulatory molecules at different developmental stages followed in most...

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Ontogeny and Effects of Thyroid Hormone on β1-Adrenergic Receptor mRNA Expression in Ovine Fetal Kidney Cortex

Jingfang Liu, Kai Chen, Nancy K. Valego, Luke C. Carey, more

Journal of the Society for Gynecologic Investigation > 2005 > 12 > 8 > 563-569

Previous studies indicate that thyroidectomy (TX) decreases renin gene expression in ovine fetal renal cortex in late gestation. Fetal ovine renin-containing renocortical cells become increasingly responsive to β-adrenergic stimulation as gestation proceeds. Increases in plasma thyroid hormone concentrations parallel this change, suggesting that there is a positive developmental relationship between...

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Developmental Changes in Adrenocorticotrophin (ACTH)-Induced Expression of ACTH Receptor and Steroid Acute Regulatory Protein mRNA in Ovine Fetal Adrenal Cells

Yixin Su, Luke C. Carey, Nancy K. Valego, James C. Rose

Journal of the Society for Gynecologic Investigation > 2005 > 12 > 6 > 416-420

Adrenocorticotrophin (ACTH) plays an important role in mediating the increase in cortisol output in the late gestation sheep fetus. At the adrenal itself, heightened expression of ACTH receptor (ACTH-R) and steroid acute regulatory protein (StAR) appear to be important parallel changes. This study examined how ACTH affects ACTH-R and StAR mRNA expression, and cortisol production in adrenocortical...

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Ontogeny of corticotropin-releasing hormone binding in anterior pituitaries of fetal sheep

Sharla F. Young, James C. Rose, Jeffrey Schwartz

Journal of the Society for Gynecologic Investigation > 2003 > 10 > 3 > 130-135

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Importance of the renal nerves for basal and stimulated renin mRNA levels in fetal and adult ovine kidneys ¹

Hiroyuki Ito, Jinjuan Wang, Jack W. Strandhoy, James C. Rose

Journal of the Society for Gynecologic Investigation > 2001 > 8 > 6 > 327-333

Objective:To investigate the effect of renal denervation on renin mRNA levels in fetal and nonpregnant adult ovine renocortical tissue and in isolated juxtaglomerular cells under basal conditions and after stimulation.Methods:The left kidney was denervated and the right kidney subjected to a sham procedure in nine ovine fetuses (136-141 days' gestation) and 20 nonpregnant ewes. After 5-7 days the...

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Maturation of cortisol responses to adrenocorticotropic hormone in twin fetal sheep in vivo

William A. Block, Michael L. Draper, James C. Rose, Jeffrey Schwartz

American Journal of Obstetrics and Gynecology > 1999 > 181 > 2 > 498-502

Objective: Adrenal steroidogenesis is important for maturation of fetal organ systems and plays a role in triggering parturition in ovine pregnancies. Studies have suggested a differential increase in baseline cortisol between twin gestations near term. Our aim was to further delineate the mechanisms responsible for the differences between the hypothalamic-pituitary-adrenal axes of twin fetuses in...

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Adenosine modulates corticotropin and cortisol release during hypoxia in fetal sheep

Andrew Chau, James C. Rose, Brian J. Koos

American Journal of Obstetrics and Gynecology > 1999 > 180 > 5 > 1272-1277

Objective: This study was designed to determine the role of adenosine in the hypoxic release of corticotropin in fetal sheep. Study Design: The adenosine receptor antagonist 8-phenyltheophylline or the vehicle was infused intra-arterially to chronically catheterized fetal sheep (>0.8 term) during an hour of fetal hypoxemia (Pa O ₂ ≅ 14 mm Hg). Control studies were also performed in which...

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Adenosine Modulates Plasma ACTH Concentrations in Fetal Sheep

Andrew Chau, James C. Rose, Brian J. Koos

Journal of the Society for Gynecologic Investigation > 1998 > 5 > 11001 > 43A

Adenosine is critically involved in the hypoxic release of fetal arginine vasopressin (AVP). Because AVP promotes the release of fetal adrenocorticotrophin (ACTH), we tested the hypothesis that adenosine mediates the hypoxia-induced rise in fetal plasma ACTH. Hypoxia was produced for one hour in eight chronically catheterized fetal sheep (> 0.8 term) by having the ewe breathe a hypoxic gas mixture...

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Developmental Changes in Renin-Containing Cells from the Ovine Fetal Kidney

Jinjuan Wang, Frank M. Perez, James C. Rose

Journal of the Society for Gynecologic Investigation > 1997 > 4 > 4 > 191-196

Objective: To determine if the increase in intrarenal renin content that occurs in late gestation in the fetal lamb results from an increase in the proportion of cells containing renin, an increase in the amount of renin per renin-containing cell, or both.Methods: Kidney cells with a density of 1.062 g/mL were isolated from ovine fetuses at 100-104 days gestation (n = 6, immature) and at 131-139 days...

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Effects of chronic infusion of angiotensin II on renin and blood pressure in the late-gestation fetal sheep

John R. Stanley, Carlos E. Giammattei, Asad U. Sheikh, Jennifer L. Green, more

American Journal of Obstetrics and Gynecology > 1997 > 176 > 4 > 931-937

OBJECTIVES: Our purpose was to determine whether chronic physiologic elevations in plasma angiotensin II levels decrease plasma renin concentration, alter the relationship between active renin and prorenin in fetal plasma and kidney, and depress the expression of renal renin messenger ribonucleic acid in the fetus. STUDY DESIGN: Seventeen chronically catheterized ovine fetuses at approximately 130...

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Hemodynamic and hormonal responses to atrial distension in the ovine fetus

Ronald K. Jaekle, Asad U. Sheikh, David D. Berry, Lisa Washburn, more

American Journal of Obstetrics and Gynecology > 1995 > 173 > 3 Part 1 > 694-701

OBJECTIVE: Our purpose ws to evaluate the hemodynamic and endocrine responses to elevations of atrial pressure in fetal sheep.STUDY DESIGN: By use of a randomized block design, 10 ovine fetuses underwent pulmonary artery constriction proximal to the ductus arteriosus with and without propranolol pretreatment.RESULTS: Atrial pressure doubled (p < 0.05), whereas mean arterial pressure remained unchanged...

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Cortisol up-regulates corticotropin releasing factor gene expression in the fetal ovine brainstem at 0.70 gestation

C. Jane Keiger, W. Keith O'Steen, Gary Brewer, Mary Sorci-Thomas, more

Molecular Brain Research > 1995 > 32 > 1 > 75-81

Glucocorticoids are important for the development of the central nervous system. In the ovine fetus, increased levels of plasma cortisol at term provide a stimulus to initiate parturition. CRF is central to this event in that it is one of the main modulators of the hypothalamic-pituitary-adrenal (HPA) axis. The purpose of the present study was to determine the effect of physiological increases in...

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Fetal oxytocin and its extended forms at term with nd without labor

Eberhard Mueller-Heubach, Mariana Morris, James C. Rose

American Journal of Obstetrics and Gynecology > 1995 > 173 > 2 > 375-381

Objective: We examined the concentrations of oxytocin and extended forms of oxytocin in umbilical plasma with and without labor.Study design: Umbilical venous and arterial blood were sampled in 27 term fetuses delivered vaginally and 13 delivered abdominally before labor. Extended forms and oxytocin were measure by radioimmunoassay and compared by analysis of variance or t test.Results: Concentrations...

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Anterior pituitary cells: getting to know their neighbors

Frank M. Perez, James C. Rose, Jeffrey Schwartz

Molecular and Cellular Endocrinology > 1995 > 111 > 2 > C1-C6

We review in this article recent findings on the effects of cell proximity (nearness to each other) on anterior pituitary cell function in vitro. Important cellular processes, including protein synthesis, basal hormone release, response to hypothalamic regulatory factors and signal transduction can change as a function of the distance between adjacent cells. These findings, together with a growing...

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Search results for: James C. Rose

Evidence for an angiotensin‐(1‐7) neuropeptidase expressed in the brain medulla and CSF of sheep

Enhanced activity of an angiotensin-(1–7) neuropeptidase in glucocorticoid-induced fetal programming

Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep

521: Renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 gender differences in fetal programmed hypertension

Seasonal protein changes support rapid energy production in hibernator brainstem

Combined Thyroidectomy and Renal Denervation Suppress Renin Expression and Secretion in Fetal Sheep

Acute and Long-Term Effects of Clinical Doses of Antenatal Glucocorticoids in the Developing Fetal Sheep Kidney

Ontogeny and Effects of Thyroid Hormone on β1-Adrenergic Receptor mRNA Expression in Ovine Fetal Kidney Cortex

Developmental Changes in Adrenocorticotrophin (ACTH)-Induced Expression of ACTH Receptor and Steroid Acute Regulatory Protein mRNA in Ovine Fetal Adrenal Cells

Ontogeny of corticotropin-releasing hormone binding in anterior pituitaries of fetal sheep

Importance of the renal nerves for basal and stimulated renin mRNA levels in fetal and adult ovine kidneys ¹

Maturation of cortisol responses to adrenocorticotropic hormone in twin fetal sheep in vivo

Adenosine modulates corticotropin and cortisol release during hypoxia in fetal sheep

Adenosine Modulates Plasma ACTH Concentrations in Fetal Sheep

Developmental Changes in Renin-Containing Cells from the Ovine Fetal Kidney

Effects of chronic infusion of angiotensin II on renin and blood pressure in the late-gestation fetal sheep

Hemodynamic and hormonal responses to atrial distension in the ovine fetus

Cortisol up-regulates corticotropin releasing factor gene expression in the fetal ovine brainstem at 0.70 gestation

Fetal oxytocin and its extended forms at term with nd without labor

Anterior pituitary cells: getting to know their neighbors

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