Search results for: Todd Manini

Items from 1 to 19 out of 19 results

article

Putative Cut‐Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis

Peggy M. Cawthon, Todd Manini, Sheena M. Patel, Anne Newman, more

Journal of the American Geriatrics Society > 68 > 7 > 1429 - 1437

OBJECTIVES Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut‐points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC‐identified metrics of low grip strength (absolute or standardized to body size/composition); low dual‐energy x‐ray absorptiometry (DXA) lean mass as previously...

article

Application of Cut‐Points for Low Muscle Strength and Lean Mass in Mobility‐Limited Older Adults

Gregory J. Grosicki, Thomas G. Travison, Hao Zhu, Jay Magaziner, more

Journal of the American Geriatrics Society > 68 > 7 > 1445 - 1453

BACKGROUND The Sarcopenia Definitions and Outcomes Consortium (SDOC) is a collaborative initiative seeking to develop and evaluate cut‐points for low muscle strength and lean mass that predict an increased risk for slowness (usual walking speed <.8 m/s) among older adults. OBJECTIVES The goal of the present study was to provide clinicians and researchers with an understanding of the diagnostic...

article

Sarcopenia Definition & Outcomes Consortium Defined Low Grip Strength in Two Cross‐Sectional, Population‐Based Cohorts

Sheena M. Patel, Kate A. Duchowny, Douglas P. Kiel, Rosaly Correa‐de‐Araujo, more

Journal of the American Geriatrics Society > 68 > 7 > 1438 - 1444

BACKGROUND/OBJECTIVES The extent to which the prevalence of muscle weakness in the US population varies by different putative grip strength constructs developed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) has not been described. DESIGN Cross‐sectional analysis. SETTING Two nationally representative cohorts—2010 and 2012 waves of the Health and Retirement Survey and round 1 (2011)...

article

Evaluation of the Potential Acetylcholinesterase Inhibitor‐Induced Rhinorrhea Prescribing Cascade

Scott Martin Vouri, Marie‐Christin Possinger, Silken Usmani, Laurence M. Solberg, more

Journal of the American Geriatrics Society > 68 > 2 > 440 - 441

article

Healthcare Utilization and Physical Functioning in Older Adults in the United States

Yue Cheng, Amie J. Goodin, Marco Pahor, Todd Manini, more

Journal of the American Geriatrics Society > 68 > 2 > 266 - 271

OBJECTIVES Decline in physical function is associated with older age. Healthcare utilization and expenditures related to physical functioning declines will likely increase as the proportion of the population of older adults rises. This study evaluated resource utilization associated with differences in physical functioning in a nationally representative sample of older adults. DESIGN A retrospective...

article

The Effects of Electrical Stimulation Pulse Duration on Lingual Palatal Pressure Measures During Swallowing in Healthy Older Adults

Ali Barikroo, Karen Hegland, Giselle Carnaby, Donald Bolser, more

Dysphagia > 2019 > 34 > 4 > 529-539

Limited research in swallowing physiology has suggested that the most common existing transcutaneous electrical stimulation (TES) protocol (VitalStim) may not penetrate to layers of tissue to affect deep swallowing muscles. TES amplitude is the primary parameter that determines the depth of electrical current penetration (DECP). Preliminary work suggests that replacing a long-pulse duration with a...

article

Self‐Reported Physical Function As a Predictor of Hospitalization in the Lifestyle Interventions and Independence for Elders Study

Kathryn E. Callahan, Laura Lovato, Michael E. Miller, Anthony P. Marsh, more

Journal of the American Geriatrics Society > 66 > 10 > 1927 - 1933

Objectives To explore whether baseline scores on the Mobility Assessment Tool—short form (MAT‐sf), a brief, animated, computer‐based means of assessing mobility that predicts mobility disability, are associated with number of hospitalizations and time to first hospitalization over a median follow‐up of 2.7 years. Design Post hoc analysis of prospectively gathered data from the Lifestyle Interventions...

article

Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations

Michael E. Miller, Jay Magaziner, Anthony P. Marsh, Roger A. Fielding, more

Journal of the American Geriatrics Society > 66 > 5 > 954 - 961

Objectives To investigate the heterogeneity of clinically meaningful levels of gait speed relative to self‐reported mobility disability (SR‐MD). Design Five longitudinal studies with older adults in different health states (onset of acute event, presence of chronic condition, sedentary, community living) were used to explore the relationship between gait speed and SR‐MD. Setting Lifestyle Interventions...

article

Osteoporosis in the Women's Health Initiative: Another Treatment Gap?

Maryam Sattari, Jane A. Cauley, Cynthia Garvan, Karen C. Johnson, more

The American Journal of Medicine > 2017 > 130 > 8 > 937-948

Osteoporotic fractures are associated with high morbidity, mortality, and cost.We performed a post hoc analysis of the Women's Health Initiative (WHI) clinical trials data to assess osteoporosis treatment and identify participant characteristics associated with utilization of osteoporosis medication(s) after new diagnoses of osteoporosis or fracture. Information from visits prior to and immediately...

article

Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial

Stephen B. Kritchevsky, Laura Lovato, Elizabeth P. Handing, Steven Blair, more

Obesity > 25 > 7 > 1199 - 1205

Objective Some data suggest that obesity blunts the benefits of exercise on mobility in older adults. This study tested the homogeneity of the effect of a physical activity intervention on major mobility disability (MMD) across baseline obesity classifications in the Lifestyle Interventions and Independence for Elders (LIFE) Study. LIFE randomized 1,635 sedentary men and women aged 70 to 89 years...

chapter

Challenges in implementing large‐scale clinical trials in moderately functioning older adults

Stephen D. Anton, Sandrine Sourdet, Marco Pahor, Todd Manini

Clinical trials in older adults > The examples > 125 - 152

Age‐related decline in both cognitive and physical function and related health care costs and services pose a major challenge for an aging society. Unfortunately, evidence‐based guidelines are lacking for treatment approaches for many conditions, such as mobility disability and dementia, common to older adults. Although large‐scale clinical trials in moderately functioning older adults are critical...

article

Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial

Mark A. Espeland, Anne B. Newman, Kaycee Sink, Thomas M. Gill, more

Journal of the American Medical Directors Association > 2015 > 16 > 8 > 682-689

The objective of this study was to evaluate cross-sectional and longitudinal associations between ankle-brachial index (ABI) and indicators of cognitive function.Randomized clinical trial (Lifestyle Interventions and Independence for Elders Trial).Eight US academic centers.A total of 1601 adults ages 70–89 years, sedentary, without dementia, and with functional limitations.Baseline ABI and interviewer-...

article

Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects

Mark A. Wallet, Thomas W. Buford, Anna-Maria Joseph, Madhuri Sankuratri, more

BMC Immunology > 2015 > 16 > 1 > 1-11

Background Systemic immune activation (inflammation) and immunosenescence develop in some people with advancing age. This process, known as “inflamm-aging,” is associated with physical frailty and sarcopenia. Meanwhile, successful antiretroviral therapy has led to a growing number of older HIV-1-infected individuals who face both age-related and HIV-1-related inflammation, which may synergistically...

article

An observational study identifying obese subgroups among older adults at increased risk of mobility disability: do perceptions of the neighborhood environment matter?

Abby C. King, Deborah Salvo, Jorge A. Banda, David K. Ahn, more

International Journal of Behavioral Nutrition and Physical Activity > 2015 > 12 > 1 > 1-19

Background Obesity is an increasingly prevalent condition among older adults, yet relatively little is known about how built environment variables may be associated with obesity in older age groups. This is particularly the case for more vulnerable older adults already showing functional limitations associated with subsequent disability. Methods The Lifestyle Interventions and Independence for Elders...

article

Combined Reduced Forced Expiratory Volume in 1 Second (FEV1) and Peripheral Artery Disease in Sedentary Elders With Functional Limitations

Carlos A. Vaz Fragoso, Fang-Chi Hsu, Tina Brinkley, Timothy Church, more

Journal of the American Medical Directors Association > 2014 > 15 > 9 > 665-670

Because they are potentially modifiable and may coexist, we evaluated the combined occurrence of a reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease (PAD), including its association with exertional symptoms, physical inactivity, and impaired mobility, in sedentary elders with functional limitations.Cross sectional.Lifestyle Interventions and Independence in Elder (LIFE)...

article

The Women’s Health Initiative

Rebecca Seguin, David M. Buchner, Jingmin Liu, Matthew Allison, more

American Journal of Preventive Medicine > 2014 > 46 > 2 > 122-135

Although epidemiologic studies have shown associations between sedentary behavior and mortality, few have focused on older women with adequate minority representation and few have controlled for both physical activity and functional status.The objective of this study was to determine the relationship between sedentary time and total; cardiovascular disease (CVD); coronary heart disease (CHD); and...

article

Prestroke Factors Associated with Poststroke Mortality and Recovery in Older Women in the Women's Health Initiative

Christina L. Bell, Andrea LaCroix, Kamal Masaki, Erinn M. Hade, more

Journal of the American Geriatrics Society > 61 > 8 > 1324 - 1330

ObjectivesTo examine prestroke lifestyle factors associated with poststroke mortality and recovery in older women. DesignLongitudinal prospective cohort study. SettingThe Women's Health Initiative (WHI, clinical trials and observational study), 40 clinical centers in the United States. ParticipantsWHI participants, women aged 50 to 79, who were stroke‐free at baseline (1993/98), with incident stroke...

article

Does Self-Reported Physical Activity Underestimate the Importance of Activity in Cardiovascular Disease Prevention?

Steve Anton, Todd Manini

Current Cardiovascular Risk Reports > 2010 > 4 > 4 > 293-301

Engagement in regular exercise or physical activity (PA) is known to protect against cardiovascular disease. Evidence for this strong association comes from both epidemiologic studies in which individuals self-report their level of PA and randomized controlled trials in which individuals increase their level of PA to a pre-defined level for a specific duration. Misclassification biases associated...

article

Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle

Emanuele Marzetti, John M. Lawler, Asimina Hiona, Todd Manini, more

Free Radical Biology and Medicine > 2008 > 44 > 2 > 160-168

Aging is inevitably associated with a progressive loss of muscle mass and strength, a condition also known as sarcopenia of aging. Although the precise mechanisms underlying this syndrome have not been completely elucidated, recent studies point toward several key cellular mechanisms that could contribute to age-associated muscle loss. Among these, mitochondrial dysfunction and deregulation of apoptotic...

Filter options

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Todd Manini

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options