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SIRT6 is a pivotal regulator of lipid metabolism. It is also closely connected to cardiovascular diseases, which are the main cause of death in diabetic patients. We observed a decrease in the expression of SIRT6 and key autophagy effectors (ATG5, LC3B, and LAMP1) in ox‐LDL‐induced foam cells, a special form of lipid‐laden macrophages. In these cells, SIRT6 WT but not SIRT6 H133Y overexpression markedly...
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