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Although temozolomide (TMZ) is the current first-line chemotherapy for glioblastoma multiforme (GBM), most patients either do not respond or ultimately fail TMZ treatment. Both intrinsic tumor resistance and limited access of TMZ to brain tumors as a result of the blood–brain barrier (BBB) contribute to poor response and ultimately to poor prognosis for GBM patients. We have developed a “dual-targeting”...