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Purpose Circadian timing system is a highly conserved, ubiquitous molecular “clock” which creates internal circadian rhythmicity. Dysregulation of clock genes expression is associated with various diseases including immune dysregulation. In this study we investigated the circadian pattern of Clock-related genes in patients with polyglandular autoimmune syndrome type III (PAS type III). Methods Nineteen...
OBJECTIVE Carriers of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) demonstrate increased secretion of Cortisol precursors following ACTH stimulation, suggestive of impaired Cortisol production and compensatory increases in hypothalamic corticotropin-releasing hormone (CRH) secretion. Both Cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion...
Adrenal sex steroids exert diverse metabolic and neurobiological actions. Their levels have been associated with cardiovascular disease, but data concerning cerebrovascular disease are lacking. The objective of our study was to investigate the role of adrenal sex steroids in a female population suffering an acute stroke. We addressed the question of whether their levels are associated with disease...
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