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The KCNE1 auxiliary subunit coassembles with the Kv7.1 channel and modulates its properties to generate the cardiac IKs current. Recent biophysical evidence suggests that KCNE1 interacts with the voltage-sensing domain (VSD) of Kv7.1. To investigate the mechanism of how KCNE1 affects the VSD to alter the voltage dependence of channel activation, we perturbed the VSD of Kv7.1 by mutagenesis and chemical...
Ca 2+ -activated BK channels modulate neuronal activities, including spike frequency adaptation and synaptic transmission. Previous studies found that Ca 2+ -binding sites and the activation gate are spatially separated in the channel protein, but the mechanism by which Ca 2+ binding opens the gate over this distance remains unknown. By studying an Asp-to-Gly mutation (D434G)...
Large conductance Ca2+- and voltage-activated K+ (BK) channels, composed of pore-forming α-subunits and auxiliary β-subunits, play important roles in diverse physiological processes. The differences in BK channel phenotypes are primarily due to the tissue-specific expression of β-subunits (β1–β4) that modulate channel function differently. Yet, the molecular basis of the subunit-specific regulation...
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