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To study the effects of inducing stereo-chemical modifications in the structure of dermorphin (DM) so as to improve its μ-opioid receptor affinity and its resistance to C-terminal enzymatic degradation, in the Institute of Molecular Genetics of Moscow, we synthesized a new DM analogue ([DPro 6 ]DM) and analyzed the changes induced in the biological activities of DM by substituting the Pro...
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