Search results for: P. Gerner

Items from 1 to 20 out of 40 results

article

Comparison of tissue distribution, phrenic nerve involvement, and epidural spread in standard- vs low-volume ultrasound-guided interscalene plexus block using contrast magnetic resonance imaging: a randomized, controlled trial† † Preliminary results of this study were presented as an abstract during the annual conference of the American Society of Regional Anesthesia (ASRA) in Las Vegas, NV, USA on May 15–16, 2015.

O. Stundner, M. Meissnitzer, C.M. Brummett, S. Moser, more

British Journal of Anaesthesia > 2016 > 116 > 3 > 405-412

Ultrasound guidance allows for the use of much lower volumes of local anaesthetics for nerve blocks, which may be associated with less aberrant spread and fewer complications. This randomized, controlled study used contrast magnetic resonance imaging to view the differential-volume local anaesthetic distribution, and compared analgesic efficacy and respiratory impairment. Thirty patients undergoing...

article

Cholezystitis

P. Gerner

Monatsschrift Kinderheilkunde > 2016 > 164 > 6 > 472-477

Die Cholezystitis kann akalkulös (ohne Steine) durch Infektionen, Traumen, Kreislaufkompromittierung oder durch Gallensteine ausgelöst werden. Virale Cholezystitiden haben eine gute Prognose und bedürfen selten einer Cholezystektomie. Bakterielle Entzündungen der Gallenblase oder Cholezystitiden als Begleiterkrankung des schwer kranken Kindes machen häufiger die operative Gallenblasenentfernung notwendig;...

article

Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats

P. Lirk, C. Verhamme, R. Boeckh, M.F. Stevens, more

British Journal of Anaesthesia > 2015 > 114 > 2 > 319-326

The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM, neuropathy would lead to increased neurotoxicity and block duration after lidocaine-induced sciatic nerve block when compared with control animals. Experiments were carried out in Zucker diabetic fatty rats aged 10 weeks (early diabetic) or...

article

Growing experience with mTOR inhibitors in pediatric solid organ transplantation

R. Ganschow, L. Pape, E. Sturm, J. Bauer, more

Pediatric Transplantation > 17 > 7 > 694 - 706

Controlled trials of mTOR inhibitors in children following solid organ transplantation are scarce, although evidence from prospective single‐arm studies is growing. Everolimus with reduced CNI therapy has been shown to be efficacious and safe in de novo pediatric kidney transplant patients in prospective trials. Prospective and retrospective data in children converted from CNI therapy to mTOR inhibition...

article

Primary HHV 6 infection after liver transplantation with acute graft rejection and multi‐organ failure: Successful treatment with a 2.5‐fold dose of cidofovir and reduction of immunosuppression

C. Dohna‐Schwake, M. Fiedler, N. Gierenz, P. Gerner, more

Pediatric Transplantation > 15 > 6 > E126 - E129

Dohna‐Schwake C, Fiedler M, Gierenz N, Gerner P, Ballauf A, Breddemann A, Läer S, Baba H. A, Hoyer P. F. Primary HHV 6 infection after liver transplantation with acute graft rejection and multi‐organ failure: Successful treatment with a 2.5‐fold dose of cidofovir and reduction of immunosuppression.  Pediatr Transplantation 2011: 15: E126–E129. © 2010 John Wiley & Sons A/S. Abstract: HHV type...

article

Gallenwegserkrankungen jenseits des Säuglingsalters

P. Gerner

Monatsschrift Kinderheilkunde > 2011 > 159 > 6 > 553-559

Die häufigsten Erkrankungen der Gallenwege werden durch Gallensteine verursacht. Sie stellen bei Jugendlichen eine wichtige Differenzialdiagnose der Oberbauchschmerzen dar. Diagnostisch kommen nichtinvasive Verfahren mittels Sonographie und MRC (Magnetresonanzcholangiographie), in Einzelfällen die Endosonographie zum Einsatz. Eine ERC (endoskopische retrograde Cholangiographie) sollte nur in Ausnahmefällen...

article

Hepatitis-C-Virusinfektion bei Kindern und Jugendlichen

S. Wirth, A. Schmidt-Choudhury, P. Bufler, P. Gerner, more

Monatsschrift Kinderheilkunde > 2010 > 158 > 6 > 593-596

______ Das vorliegende Konsensuspapier stellt einen Auszug aus folgender Leitlinie dar: Update der S3-Leitlinie Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus (HCV)-Infektion, AWMF-Register-Nr.: 021/012. Prophylaxis, Diagnosis and Therapy of Hepatitis C Virus (HCV) Infection: The German Guidelines on the Management of HCV Infection.

article

Akutes Leberversagen im Kindesalter

P. Gerner, P.F. Hoyer

Monatsschrift Kinderheilkunde > 2009 > 157 > 11 > 1157-1168

Das akute Leberversagen, eine hepatisch bedingte Gerinnungsstörung mit INR (INR: „international normalized ratio“) ≥1,5 (nicht durch Vitamin-K-Gabe korrigierbar) mit oder INR≥2,0 ohne Enzephalopathie, ist lebensbedrohlich. Unter Ausschöpfung aller Therapiemöglichkeiten werden heute durch frühzeitige Verlegung in ein Transplantationszentrum Überlebensraten von rund 70% erreicht. Im Neugeborenen- und...

article

Hepatitis B und C im Kindesalter

P. Gerner, S. Wirth

Monatsschrift Kinderheilkunde > 2009 > 157 > 2 > 177-188

Bei Kindern ist die Therapie einer chronischen Hepatitis B in der hochvirämischen Phase indiziert, falls die Transaminasen mehrmals erhöht waren oder eine Leberfibrose ab Grad 2 oder soziale Umstände eine HBV(Hepatitis-B-Virus)-Suppression nötig machen. Die Behandlung mit α-Interferon (IFN-α) ist die Therapie der 1. Wahl. Sie führt bei 26–38% der Patienten zu einer Anti-HBe(„hepatitis B protein e...

article

The significance of the number of submitted samples and patient-related factors for faecal bacterial diagnostics

S. Ethelberg, K.E.P. Olsen, P. Gerner-Smidt, K. Mølbak

Clinical Microbiology and Infection > 2007 > 13 > 11 > 1095-1099

The sensitivity of bacteriological testing of faecal samples from patients with diarrhoea has not been properly determined. The present study analysed the association between the results of stool sample examinations and the number of samples examined per patient and other patient-related factors. Data concerning faecal specimens referred for culture for enteric bacterial pathogens (Campylobacter,...

article

Attaching and effacing Escherichia coli isolates from Danish children: clinical significance and microbiological characteristics

C. Jensen, S. Ethelberg, B. Olesen, P. Schiellerup, more

Clinical Microbiology and Infection > 2007 > 13 > 9 > 863-872

This study describes the prevalence, clinical manifestations and microbiological characteristics of attaching and effacing Escherichia coli isolates, i.e., enteropathogenic E. coli (EPEC) belonging to the classical EPEC serotypes, non-EPEC attaching and effacing E. coli (A/EEC) and verocytotoxin-producing E. coli (VTEC), isolated in a case-control study of Danish children aged <5 years. Among 424...

article

A method for fast and simple detection of major diarrhoeagenic Escherichia coli in the routine diagnostic laboratory

S. Persson, K.E.P. Olsen, F. Scheutz, K.A. Krogfelt, more

Clinical Microbiology and Infection > 2007 > 13 > 5 > 516-524

A multiplex PCR was developed for the detection of the following genes characteristic of diarrhoeagenic Escherichia coli (DEC): verocytotoxins 1 (vtx1) and 2 (vtx2), characteristic of verocytotoxin-producing E. coli (VTEC); intimin (eae), found in enteropathogenic E. coli (EPEC), attaching and effacing E. coli and VTEC; heat-stable enterotoxin (estA) and heat-labile enterotoxin (eltA), characteristic...

article

Phase 1A safety assessment of intravenous amitriptyline used as a pre-emptive analgesic prior to shoulder or thoracic surgery

A. Wasan, P. Lirk, P. Gerner

Journal of Pain > 2007 > 8 > 4 Supplement > S47

article

Guidelines for the validation and application of typing methods for use in bacterial epidemiology

A. van Belkum, P.T. Tassios, L. Dijkshoorn, S. Haeggman, more

Clinical Microbiology and Infection > 2007 > 13 > Supplement 3 > 1-46

For bacterial typing to be useful, the development, validation and appropriate application of typing methods must follow unified criteria. Over a decade ago, ESGEM, the ESCMID (Europen Society for Clinical Microbiology and Infectious Diseases) Study Group on Epidemiological Markers, produced guidelines for optimal use and quality assessment of the then most frequently used typing procedures. We present...

article

Axonal neurotoxicity of local anesthetics in compartmented rat dorsal root ganglion cell cultures

I. Haller, L. Klimaschewski, P. Gerner, P. Lirk

Regional Anesthesia and Pain Medicine > 2006 > 31 > 5 Supplement > 4

article

Neurotoxicity of bupivacaine, but not ropivacaine, is attenuated by inhibition of mitogen-activated protein kinases

H.P. Colvin, I. Haller, L. Klimaschewski, P. Gerner, more

Regional Anesthesia and Pain Medicine > 2006 > 31 > 5 Supplement > 94

article

Neurotoxic properties of the investigational local anesthetic adjuvant ephedrine

I. Haller, L. Klimaschewski, P. Gerner, P. Lirk

Regional Anesthesia and Pain Medicine > 2006 > 31 > 5 Supplement > 4

article

Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 map kinase in vitro and in vivo

P. Lirk, I. Haller, L. Klimaschewski, P. Gerner

Regional Anesthesia and Pain Medicine > 2005 > 30 > 5 Supplement > 6

article

Invasive listeriosis in Denmark 1994–2003: a review of 299 cases with special emphasis on risk factors for mortality

P. Gerner-Smidt, S. Ethelberg, P. Schiellerup, J.J. Christensen, more

Clinical Microbiology and Infection > 2005 > 11 > 8 > 618-624

Listeriosis is a rare, but serious, foodborne infection which, in the invasive form, presents as bloodstream (BS) infection, an infection of the central nervous system (CNS), a maternofetal infection or a focal infection. The disease is notifiable in Denmark. This paper reviews the results of the Danish surveillance of invasive listeriosis from 1994 to 2003, excluding maternofetal cases. In total,...

article

Campylobacter concisus: an evaluation of certain phenotypic and genotypic characteristics

J. Engberg, D.D. Bang, R. Aabenhus, F.M. Aarestrup, more

Clinical Microbiology and Infection > 2005 > 11 > 4 > 288-295

The clinical relevance of Campylobacter concisus in gastrointestinal disease has not been determined definitively. This study investigated the phenotypic and genotypic characteristics of 39 C. concisus isolates from Danish patients with diarrhoea, three isolates from healthy individuals and the type strain. A cytolethal distending toxin (CDT)-like effect on Vero cells was observed in 35 (90%) isolates...

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Search results for: P. Gerner

Cholezystitis

Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats

Growing experience with mTOR inhibitors in pediatric solid organ transplantation

Primary HHV 6 infection after liver transplantation with acute graft rejection and multi‐organ failure: Successful treatment with a 2.5‐fold dose of cidofovir and reduction of immunosuppression

Gallenwegserkrankungen jenseits des Säuglingsalters

Hepatitis-C-Virusinfektion bei Kindern und Jugendlichen

Akutes Leberversagen im Kindesalter

Hepatitis B und C im Kindesalter

The significance of the number of submitted samples and patient-related factors for faecal bacterial diagnostics

Attaching and effacing Escherichia coli isolates from Danish children: clinical significance and microbiological characteristics

A method for fast and simple detection of major diarrhoeagenic Escherichia coli in the routine diagnostic laboratory

Phase 1A safety assessment of intravenous amitriptyline used as a pre-emptive analgesic prior to shoulder or thoracic surgery

Guidelines for the validation and application of typing methods for use in bacterial epidemiology

Axonal neurotoxicity of local anesthetics in compartmented rat dorsal root ganglion cell cultures

Neurotoxicity of bupivacaine, but not ropivacaine, is attenuated by inhibition of mitogen-activated protein kinases

Neurotoxic properties of the investigational local anesthetic adjuvant ephedrine

Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 map kinase in vitro and in vivo

Invasive listeriosis in Denmark 1994–2003: a review of 299 cases with special emphasis on risk factors for mortality

Campylobacter concisus: an evaluation of certain phenotypic and genotypic characteristics

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